Concise review: new frontiers in MicroRNA-based tissue regeneration

Frith, Jessica E., Porrello, Enzo R. and Cooper-White, Justin J. (2014) Concise review: new frontiers in MicroRNA-based tissue regeneration. Stem Cells Translational Medicine, 3 8: 969-976. doi:10.5966/sctm.2014-0032

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Author Frith, Jessica E.
Porrello, Enzo R.
Cooper-White, Justin J.
Title Concise review: new frontiers in MicroRNA-based tissue regeneration
Journal name Stem Cells Translational Medicine   Check publisher's open access policy
ISSN 2157-6564
Publication date 2014-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.5966/sctm.2014-0032
Open Access Status
Volume 3
Issue 8
Start page 969
End page 976
Total pages 8
Place of publication Durham, NC, United States
Publisher AlphaMed Press
Collection year 2015
Language eng
Abstract In recent years, the role of miRNAs in post-transcriptional gene regulation has come to the fore with strong evidence to indicate an important role for microRNAs (miRNAs) in the regulation of a wide range of fundamental biological processes. Notably, this includes the regulation of both endogenous tissue repair mechanisms and the growth and differentiation of stem cells (both adult and pluripotent). As a result, manipulation of miRNA signaling holds great promise for regenerative medicine, which aims to harness either endogenous or implanted cells to promote tissue repair. However, to fully realize this potential, it will be necessary to combine advances in our biological understanding with new technologies that allow precise spatiotemporal modulation of specific miRNA candidates. In this review, we highlight the role of miRNAs in tissue regeneration, discuss key challenges in translating this knowledge to the clinic, and outline recent technological advances that aim to address these issues. By combining a comprehensive knowledge of miRNA biology with cutting-edge delivery technologies, it is clear that miRNAs hold significant promise for tissue regenerative therapies in the future.
Keyword Delivery systems
Stem cells
Tissue regeneration
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: School of Chemical Engineering Publications
Official 2015 Collection
School of Biomedical Sciences Publications
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Tue, 05 Aug 2014, 17:10:52 EST by Dr Jessica Frith on behalf of Aust Institute for Bioengineering & Nanotechnology