Transcriptional control of mesenchymal stem cell differentiation

Frith, Jess and Genever, Paul (2008) Transcriptional control of mesenchymal stem cell differentiation. Transfusion Medicine and Hemotherapy, 35 3: 216-227. doi:10.1159/000127448


Author Frith, Jess
Genever, Paul
Title Transcriptional control of mesenchymal stem cell differentiation
Journal name Transfusion Medicine and Hemotherapy   Check publisher's open access policy
ISSN 1660-3796
1660-3818
Publication date 2008-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1159/000127448
Open Access Status
Volume 35
Issue 3
Start page 216
End page 227
Total pages 12
Place of publication Basel, Switzerland
Publisher S. Karger
Language eng
Formatted abstract
In recent years, transcriptomics and proteomics have provided us with a great deal of information about the expression profiles of various cell types and how these change under different conditions. Stem cell research is one area where this has had a major impact by providing an insight into events at the molecular level that control stem cell growth and differentiation. This includes mesenchymal stem cell (MSC) biology where know ledge about the mechanisms governing differentiation is vital for the development of future therapeutic strategies. Although there is still much to learn, we are starting to build up a picture of the main events in these differentiation processes. This review will discuss control of MSC differentiation at the transcriptional level. Not all the factors which have been shown to play a role in lineage-specific mesenchymal differentiation can be covered here. Instead, we will focus specifically on the key factors that contribute to the regulation of osteogenesis, adipogenesis, and chondrogenesis.
Keyword MSCs
Cbfa-1
PPAR-γ
Sox9
Transcription factors
PPAR-gamma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 23 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 05 Aug 2014, 16:55:20 EST by Dr Jessica Frith on behalf of Aust Institute for Bioengineering & Nanotechnology