The Handan eye study: comparison of screening methods for primary angle closure suspects in a rural Chinese population

Zhang, Ye, Li, Si Zhen, Li, Lei, Thomas, Ravi and Wang, Ning Li (2014) The Handan eye study: comparison of screening methods for primary angle closure suspects in a rural Chinese population. Ophthalmic Epidemiology, 21 4: 268-275. doi:10.3109/09286586.2014.929707


Author Zhang, Ye
Li, Si Zhen
Li, Lei
Thomas, Ravi
Wang, Ning Li
Title The Handan eye study: comparison of screening methods for primary angle closure suspects in a rural Chinese population
Journal name Ophthalmic Epidemiology   Check publisher's open access policy
ISSN 1744-5086
0928-6586
Publication date 2014-08
Year available 2014
Sub-type Article (original research)
DOI 10.3109/09286586.2014.929707
Open Access Status
Volume 21
Issue 4
Start page 268
End page 275
Total pages 8
Place of publication London, United Kingdom
Publisher Informa Healthcare
Collection year 2015
Language eng
Formatted abstract
Objective: To evaluate the van Herick test, anterior segment optical coherence tomography (AS-OCT), Pentacam and scanning peripheral anterior chamber depth analyzer (SPAC) for detecting primary angle-closure suspect (PACS) in a rural Chinese population.

Methods: Eligible subjects aged ≥40 years were examined at the 5-year follow-up of the Handan Eye Study. PACS was defined as non-visibility of the posterior pigmented trabecular meshwork for ≥180° of the angle. Sensitivity, specificity, predictive values and receiver operating characteristic curves were used to assess the tests.

Results: A total of 425 right eyes of 431 eligible subjects were analyzed. The area under the curve (AUC) for the van Herick test and AS-OCT were 0.711 and 0.799, respectively. The AUC for Pentacam anterior chamber depth was 0.834, while anterior chamber angle and anterior chamber volume had AUCs of 0.680 and 0.800, respectively. The AUC for SPAC was 0.779. AS-OCT had a specificity of 87% with a sensitivity of 73%. The best specificity of 92% (sensitivity 19%) was achieved by the van Herrick test at the 15% cut-off.

Conclusions: None of the tests evaluated achieved the combination of specificity and sensitivity needed for population-based screening and their current capability does not realize the objective of case detection in the setting of an ophthalmology clinic.




Keyword Anterior segment OCT
Case detection
Pentacam
Primary angle closure suspect
Scanning peripheral anterior chamber depth analyzer
Screening
Van herick test
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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