Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming

Chow, Melvyn T., Duret, Helene, Andrews, Daniel M., Faveeuw, Christelle, Moller, Andreas, Smyth, Mark J. and Paget, Christophe (2014) Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming. European Journal of Immunology, 44 7: 2111-2120. doi:10.1002/eji.201344329

Author Chow, Melvyn T.
Duret, Helene
Andrews, Daniel M.
Faveeuw, Christelle
Moller, Andreas
Smyth, Mark J.
Paget, Christophe
Title Type I NKT-cell-mediated TNF-α is a positive regulator of NLRP3 inflammasome priming
Journal name European Journal of Immunology   Check publisher's open access policy
ISSN 1521-4141
Publication date 2014-07
Year available 2014
Sub-type Article (original research)
DOI 10.1002/eji.201344329
Open Access Status
Volume 44
Issue 7
Start page 2111
End page 2120
Total pages 10
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Collection year 2015
Language eng
Abstract The NLRP3 inflammasome plays a crucial role in the innate immune response to pathogens and exogenous or endogenous danger signals. Its activity must be precisely and tightly regulated to generate tailored immune responses. However, the immune cell subsets and cytokines controlling NLRP3 inflammasome activity are still poorly understood. Here, we have shown a link between NKT-cell-mediated TNF-α and NLRP3 inflammasome activity. The NLRP3 inflammasome in APCs was critical to potentiate NKT-cell-mediated immune responses, since C57BL/6 NLRP3 inflammasome-deficient mice exhibited reduced responsiveness to α-galactosylceramide. Importantly, NKT cells were found to act as regulators of NLRP3 inflammasome signaling, as NKT-cell-derived TNF-α was required for optimal IL-1β and IL-18 production by myeloid cells in response to α-galactosylceramide, by acting on the NLRP3 inflammasome priming step. Thus, NKT cells play a role in the positive regulation of NLRP3 inflammasome priming by mediating the production of TNF-α, thus demonstrating another means by which NKT cells control early inflammation.
Keyword Inflammasome
NKT cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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