Copper removal strategies for Wilson's disease crisis in the ICU

Reynolds, H. V., Talekar, C. R., Bellapart, J., Leggett, B. A. and Boots, R. J. (2014) Copper removal strategies for Wilson's disease crisis in the ICU. Anaesthesia and Intensive Care, 42 2: 253-257.

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Author Reynolds, H. V.
Talekar, C. R.
Bellapart, J.
Leggett, B. A.
Boots, R. J.
Title Copper removal strategies for Wilson's disease crisis in the ICU
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
1448-0271
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
Open Access Status
Volume 42
Issue 2
Start page 253
End page 257
Total pages 5
Place of publication Sydney, NSW Australia
Publisher Australian Society of Anaesthetists
Collection year 2015
Language eng
Formatted abstract
Wilson's disease is a rare, inherited, autosomal recessive disorder of copper metabolism which leads to an accumulation of copper in body tissues. If a patient develops a Wilson's crisis, mortality can approach 100%. The treatment of such patients is mostly organ support but a possible treatment goal is to try to rapidly remove copper from their system. We performed a literature search on methods for de-coppering strategies for patients in intensive care with known Wilson's disease. We found 11 case reports where therapeutic plasma exchange was used and six case reports where various forms of albumin dialysis were used as techniques for rapidly reducing serum copper levels. To date, the case reports are encouraging that therapeutic plasma exchange and albumin dialysis can either delay or prevent the need for liver transplantation in patients with fulminant hepatic failure due to Wilson's disease. However, these case reports are mainly in the paediatric or young adult population, thus further studies in adults are warranted.
Keyword Albumin dialysis
Copper
Haemolysis
Molecular adsorbent recirculating system
Plasma exchange
Wilson's disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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