Quantitative analysis of iris changes after physiologic and pharmacologic mydriasis in a rural Chinese population

Zhang, Ye, Li, Si Zhen, Li, Lei, He, Ming Guang, Thomas, Ravi and Wang, Ning Li (2014) Quantitative analysis of iris changes after physiologic and pharmacologic mydriasis in a rural Chinese population. Investigative Ophthalmology and Visual Science, 55 7: 4405-4412. doi:10.1167/iovs.13-13782


Author Zhang, Ye
Li, Si Zhen
Li, Lei
He, Ming Guang
Thomas, Ravi
Wang, Ning Li
Title Quantitative analysis of iris changes after physiologic and pharmacologic mydriasis in a rural Chinese population
Journal name Investigative Ophthalmology and Visual Science   Check publisher's open access policy
ISSN 1552-5783
0146-0404
Publication date 2014-07-17
Year available 2014
Sub-type Article (original research)
DOI 10.1167/iovs.13-13782
Open Access Status
Volume 55
Issue 7
Start page 4405
End page 4412
Total pages 8
Place of publication Rockville, MD, United States
Publisher Association for Research in Vision and Ophthalmology
Collection year 2015
Language eng
Formatted abstract
Purpose. To estimate and compare the change in iris cross-sectional area (IA) and iris volume (IV) following physiologic and pharmacologic pupil dilation in primary angle closure suspects (PACS) and normal subjects.

Methods. Anterior segment-optical coherence tomography (AS-OCT) measurements in light, dark, and following pharmacologic dilation were obtained on 186 PACS and 224 normal subjects examined during the 5-year follow-up of the Handan Eye Study. Iris cross-sectional area, IV, and other biometric parameters calculated using the Zhongshan angle assessment program in the right eyes of all subjects were analyzed.

Results. The mean IA and IV decreased in dark compared with light and after pharmacologic dilation in both PACS and normal eyes. This change was statistically significant in normal eyes: light versus pharmacologic dilation for IA (P= 0.038) and for IV, both light versus dark (P= 0.031) and light versus pharmacologic dilation (P= 0.012). A longer axial length (P= 0.028) and a greater change in pupil diameter (PD) (P<0.001) were associated with a larger decrease of IA for the light to dark comparison. A diagnosis of normal eyes (P= 0.011), larger PD in dark (P= 0.001), and a larger change in PD (P= 0.001) were associated with a larger decrease of IV from light to dark.

Conclusions. The differences in iris behavior between PACS and normal rural Chinese subjects following physiologic or pharmacologic pupillary dilation may help provide insights into the pathogenesis of angle closure.
Keyword Anterior segment-optical coherence tomography
Primary angle closure suspect
Iris volume change
Iris cross-sectional area change
Mydriasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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