The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

Cross, Marita, Smith, Emma, Hoy, Damian, Nolte, Sandra, Ackerman, Ilana, Fransen, Marlene, Bridgett, Lisa, Williams, Sean, Guillemin, Francis, Hill, Catherine L., Laslett, Laura L., Jones, Graeme, Cicuttini, Flavia, Osborne, Richard, Vos, Theo, Buchbinder, Rachelle, Woolf, Anthony and March, Lyn (2014) The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Annals of the Rheumatic Diseases, 73 7: 1323-1330. doi:10.1136/annrheumdis-2013-204763

Author Cross, Marita
Smith, Emma
Hoy, Damian
Nolte, Sandra
Ackerman, Ilana
Fransen, Marlene
Bridgett, Lisa
Williams, Sean
Guillemin, Francis
Hill, Catherine L.
Laslett, Laura L.
Jones, Graeme
Cicuttini, Flavia
Osborne, Richard
Vos, Theo
Buchbinder, Rachelle
Woolf, Anthony
March, Lyn
Title The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study
Journal name Annals of the Rheumatic Diseases   Check publisher's open access policy
ISSN 1468-2060
Publication date 2014-07
Sub-type Article (original research)
DOI 10.1136/annrheumdis-2013-204763
Open Access Status
Volume 73
Issue 7
Start page 1323
End page 1330
Total pages 8
Place of publication London, United Kingdom
Publisher B M J Group
Collection year 2015
Language eng
Formatted abstract
Objective To estimate the global burden of hip and knee osteoarthritis (OA) as part of the Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA compares with other conditions.

Methods Systematic reviews were conducted to source age-specific and sex-specific epidemiological data for hip and knee OA prevalence, incidence and mortality risk. The prevalence and incidence of symptomatic, radiographic and self-reported hip or knee OA were included. Three levels of severity were defined to derive disability weights (DWs) and severity distribution (proportion with mild, moderate and severe OA). The prevalence by country and region was multiplied by the severity distribution and the appropriate disability weight to calculate years of life lived with disability (YLDs). As there are no deaths directly attributed to OA, YLDs equate disability-adjusted life years (DALYs).

Results Globally, of the 291 conditions, hip and knee OA was ranked as the 11th highest contributor to global disability and 38th highest in DALYs. The global age-standardised prevalence of knee OA was 3.8% (95% uncertainty interval (UI) 3.6% to 4.1%) and hip OA was 0.85% (95% UI 0.74% to 1.02%), with no discernible change from 1990 to 2010. Prevalence was higher in females than males. YLDs for hip and knee OA increased from 10.5 million in 1990 (0.42% of total DALYs) to 17.1 million in 2010 (0.69% of total DALYs).

Conclusions Hip and knee OA is one of the leading causes of global disability. Methodological issues within this study make it highly likely that the real burden of OA has been underestimated. With the aging and increasing obesity of the world's population, health professions need to prepare for a large increase in the demand for health services to treat hip and knee OA.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Public Health Publications
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