Hippocampal 5-HT1A receptor binding is related to object–location memory in humans

Glikmann-Johnston, Yifat, Saling, Michael M., Chen, Jian, O’Keefe, Graeme, Gong, Sylvia, Tochon-Danguy, Henri, Mulligan, Rachel and Reutens, David C. (2014) Hippocampal 5-HT1A receptor binding is related to object–location memory in humans. Brain Structure and Function, 220 1: 559-570. doi:10.1007/s00429-013-0675-7


Author Glikmann-Johnston, Yifat
Saling, Michael M.
Chen, Jian
O’Keefe, Graeme
Gong, Sylvia
Tochon-Danguy, Henri
Mulligan, Rachel
Reutens, David C.
Title Hippocampal 5-HT1A receptor binding is related to object–location memory in humans
Formatted title
Hippocampal 5-HT1A receptor binding is related to object–location memory in humans
Journal name Brain Structure and Function   Check publisher's open access policy
ISSN 1863-2653
1863-2661
Publication date 2014-05-08
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s00429-013-0675-7
Open Access Status
Volume 220
Issue 1
Start page 559
End page 570
Total pages 12
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2015
Language eng
Formatted abstract
Animal studies suggest that serotonin, mediated by the 5-HT1A receptor, plays a key role in spatial learning and memory. The role of serotonin in spatial memory in humans has, however, been less well studied. This study examined the relationship between serotonin receptor density in the human brain and spatial learning and memory using the 5-HT1A receptor ligand 18F-4-(2′-methoxyphenyl)-1-[2′-(N-2-pyridinyl)-p-fluorobenzamido]-ethyl-piperazine ([18F] MPPF) and positron emission tomography (PET). Ten neurologically healthy individuals underwent two [18F] MPPF PET scans, one while performing a task which involves processing of high-level spatial information (‘house scan’), and one while performing a task which involves processing of low-level spatial information (‘tunnel scan’). Navigation, recall of arbitrary associations between objects and their spatial location, and ability to draw a plan of the environment were tested following the house scan. 5-HT1A receptor binding did not differ significantly between processing high and low levels of spatial information. Hippocampal asymmetry in [18F] MPPF binding, however, was associated with memory for object–location associations; lower right than left hippocampal binding potential (BPND) was related to better memory performance. We conclude that hippocampal serotonergic function plays a role in a fundamental component of human spatial memory, the ability to recall the location of encountered objects.
Keyword Serotonin 1A receptor
Positron emission tomography
[18 F] MPPF
Hippocampus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Centre for Advanced Imaging Publications
 
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Created: Fri, 01 Aug 2014, 10:48:21 EST by Sandrine Ducrot on behalf of Centre for Advanced Imaging