Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively

Enoksson, Tomas, Bertran-Gonzalez, Jesus and Christie, MacDonald J (2012) Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively. Neuropharmacology, 62 8: 2463-2471. doi:10.1016/j.neuropharm.2012.02.020

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Author Enoksson, Tomas
Bertran-Gonzalez, Jesus
Christie, MacDonald J
Title Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively
Journal name Neuropharmacology   Check publisher's open access policy
ISSN 0028-3908
1873-7064
Publication date 2012-06
Sub-type Article (original research)
DOI 10.1016/j.neuropharm.2012.02.020
Open Access Status File (Author Post-print)
Volume 62
Issue 8
Start page 2463
End page 2471
Total pages 9
Place of publication Oxford United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
Opioids are effective analgesic agents but serious adverse effects such as tolerance and withdrawal contribute to opioid dependence and limit their use. Opioid withdrawal involves numerous brain regions and includes suppression of dopamine release and activation of neurons in the ventral striatum. By contrast, acute opioids increase dopamine release. Like withdrawal, acute opioids also activate neurons in the ventral striatum, suggesting that different populations of ventral striatal neurons may be activated by withdrawal and acute opioid actions. Here, immunofluorescence for the activity-related immediate-early gene, c-Fos, was examined in transgenic reporter mouse lines by confocal microscopy to study the specific populations of ventral striatal neurons activated by morphine withdrawal and acute morphine. After chronic morphine, naloxone-precipitated withdrawal strongly increased expression of c-Fos immunoreactivity, predominantly in D2-receptor (D2R) medium-sized spiny neurons (MSNs) of the nucleus accumbens (NAc) core and shell regions. By contrast, a single injection of morphine exclusively activated c-Fos immunoreactivity in D1-receptor expressing (D1R) MSNs of the core and shell of the NAc. These results reveal a striking segregation of neuronal responses occurring in the two populations of MSNs of the NAc in response to morphine withdrawal and acute morphine.
Keyword Opioids
Striatonigral neurons
Striatopallidal neurons
Opioid dependence
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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Created: Tue, 29 Jul 2014, 14:47:09 EST by J Bertran Gonzalez on behalf of Clem Jones Centre for Ageing Dementia Research