Does the microbiome play a causal role in spondyloarthritis?

Rosenbaum, James T., Lin, Phoebe, Asquith, Mark, Costello, Mary-Ellen, Kenna, Tony J. and Brown, Matthew A. (2014) Does the microbiome play a causal role in spondyloarthritis?. Clinical Rheumatology, 33 6: 763-767. doi:10.1007/s10067-014-2664-5

Author Rosenbaum, James T.
Lin, Phoebe
Asquith, Mark
Costello, Mary-Ellen
Kenna, Tony J.
Brown, Matthew A.
Title Does the microbiome play a causal role in spondyloarthritis?
Journal name Clinical Rheumatology   Check publisher's open access policy
ISSN 1434-9949
Publication date 2014-06-01
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s10067-014-2664-5
Open Access Status
Volume 33
Issue 6
Start page 763
End page 767
Total pages 5
Place of publication London, United Kingdom
Publisher Springer U K
Collection year 2015
Language eng
Abstract The purpose of this study is to review the potential causal role of the microbiome in the pathogenesis of spondyloarthritis. The method used for the study is literature review. The microbiome plays a major role in educating the immune response. The microbiome is strongly implicated in inflammatory bowel disease which has clinical and genetic overlap with spondyloarthritis. The microbiome also plays a causal role in bowel and joint disease in HLA B27/human beta 2 microglobulin transgenic rats. The mechanism(s) by which HLA B27 could influence the microbiome is unknown but theories include an immune response gene selectivity, an effect on dendritic cell function, or a mucosal immunodeficiency. Bacteria are strongly implicated in the pathogenesis of spondyloarthritis. Studies to understand how HLA B27 affects bacterial ecosystems should be encouraged.
Keyword Inflammatory bowel disease
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
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