Principles and operational parameters to optimize poison removal with extracorporeal treatments

Bouchard, Josée, Roberts, Darren M., Roy, Louise, Ouellet, Georges, Decker, Brian S., Mueller, Bruce A., Desmeules, Simon and Ghannoum, Marc (2014) Principles and operational parameters to optimize poison removal with extracorporeal treatments. Seminars in Dialysis, 27 4: 371-380. doi:10.1111/sdi.12247


Author Bouchard, Josée
Roberts, Darren M.
Roy, Louise
Ouellet, Georges
Decker, Brian S.
Mueller, Bruce A.
Desmeules, Simon
Ghannoum, Marc
Title Principles and operational parameters to optimize poison removal with extracorporeal treatments
Journal name Seminars in Dialysis   Check publisher's open access policy
ISSN 1525-139X
0894-0959
Publication date 2014-07
Year available 2014
Sub-type Article (original research)
DOI 10.1111/sdi.12247
Open Access Status
Volume 27
Issue 4
Start page 371
End page 380
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell Publishing
Collection year 2015
Language eng
Abstract A role for nephrologists in the management of a poisoned patient involves evaluating the indications for, and methods of, enhancing the elimination of a poison. Nephrologists are familiar with the various extracorporeal treatments (ECTRs) used in the management of impaired kidney function, and their respective advantages and disadvantages. However, these same skills and knowledge may not always be considered, or applicable, when prescribing ECTR for the treatment of a poisoned patient. Maximizing solute elimination is a key aim of such treatments, perhaps more so than in the treatment of uremia, because ECTR has the potential to reverse clinical toxicity and shorten the duration of poisoning. This manuscript reviews the various principles that govern poison elimination by ECTR (diffusion, convection, adsorption, and centrifugation) and how components of the ECTR can be adjusted to maximize clearance. Data supporting these recommendations will be presented, whenever available.
Keyword Extracorporeal treatments
Poison
Solute elimination
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published: JUL-AUG 2014

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Tue, 29 Jul 2014, 01:53:14 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH