Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: Facts and perspectives

Galli, Daniela, Vitale, Marco and Vaccarezza, Mauro (2014) Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: Facts and perspectives. BioMed Research International, 2014 . doi:10.1155/2014/762695


Author Galli, Daniela
Vitale, Marco
Vaccarezza, Mauro
Title Bone marrow-derived mesenchymal cell differentiation toward myogenic lineages: Facts and perspectives
Journal name BioMed Research International   Check publisher's open access policy
ISSN 2314-6133
2314-6141
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1155/2014/762695
Open Access Status DOI
Volume 2014
Total pages 6
Place of publication New York, NY United States
Publisher Hindawi Publishing Corporation
Collection year 2015
Language eng
Abstract Bone marrow-derived mesenchymal stem cells (BM-MSCs) are valuable platforms for new therapies based on regenerative medicine. BM-MSCs era is coming of age since the potential of these cells is increasingly demonstrated. In fact, these cells give origin to osteoblasts, chondroblasts, and adipocyte precursors in vitro, and they can also differentiate versus other mesodermal cell types like skeletal muscle precursors and cardiomyocytes. In our short review, we focus on the more recent manipulations of BM-MSCs toward skeletal and heart muscle differentiation, a growing field of obvious relevance considering the toll of muscle disease (i.e., muscular dystrophies), the heavier toll of heart disease in developed countries, and the still not completely understood mechanisms of muscle differentiation and repair.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Biomedical Sciences Publications
 
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