Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer

Askarian-Amiri, Marjan E., Seyfoddin, Vahid, Smart, Chanel E., Wang, Jingli, Kim, Ji Eun, Hansji, Herah, Baguley, Bruce C., Finlay, Graeme J. and Leung, Euphemia Y. (2014) Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer. PLoS One, 9 7: e102140.1-e102140.10. doi:10.1371/journal.pone.0102140

Author Askarian-Amiri, Marjan E.
Seyfoddin, Vahid
Smart, Chanel E.
Wang, Jingli
Kim, Ji Eun
Hansji, Herah
Baguley, Bruce C.
Finlay, Graeme J.
Leung, Euphemia Y.
Title Emerging role of long non-coding RNA SOX2OT in SOX2 regulation in breast cancer
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-07-09
Sub-type Article (original research)
DOI 10.1371/journal.pone.0102140
Open Access Status DOI
Volume 9
Issue 7
Start page e102140.1
End page e102140.10
Total pages 10
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2015
Language eng
Abstract The transcription factor SOX2 is essential for maintaining pluripotency in a variety of stem cells. It has important functions during embryonic development, is involved in cancer stem cell maintenance, and is often deregulated in cancer. The mechanism of SOX2 regulation has yet to be clarified, but the SOX2 gene lies in an intron of a long multi-exon non-coding RNA called SOX2 overlapping transcript (SOX2OT). Here, we show that the expression of SOX2 and SOX2OT is concordant in breast cancer, differentially expressed in estrogen receptor positive and negative breast cancer samples and that both are up-regulated in suspension culture conditions that favor growth of stem cell phenotypes. Importantly, ectopic expression of SOX2OT led to an almost 20-fold increase in SOX2 expression, together with a reduced proliferation and increased breast cancer cell anchorage-independent growth. We propose that SOX2OT plays a key role in the induction and/or maintenance of SOX2 expression in breast cancer.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
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