Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake

Yang, Yannan, Karmakar, Surajit, Zhang, Jun, Yu, Meihua, Mitter, Neena and Yu, Chengzhong (2014) Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake. Journal of Materials Chemistry B, 2 30: 4929-4934. doi:10.1039/c4tb00595c

Author Yang, Yannan
Karmakar, Surajit
Zhang, Jun
Yu, Meihua
Mitter, Neena
Yu, Chengzhong
Title Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake
Journal name Journal of Materials Chemistry B   Check publisher's open access policy
ISSN 2050-750X
Publication date 2014-08-14
Year available 2014
Sub-type Article (original research)
DOI 10.1039/c4tb00595c
Open Access Status Not Open Access
Volume 2
Issue 30
Start page 4929
End page 4934
Total pages 6
Place of publication Cambridge, United Kingdom
Publisher Royal Society of Chemistry
Collection year 2015
Language eng
Subject 1600 Chemistry
2204 Religion and Religious Studies
2700 Medicine
2500 Materials Science
Abstract Small sized SBA-15 rods with 80-200 nm in length, 18 ± 8 nm in width and a pore size of 8.3 nm have been successfully synthesized by finely tuning the synthesis pH in a narrow range of 3.40-3.88. Compared to traditional SBA-15 with relatively larger particle sizes and MCM-41 with smaller pore sizes, SBA-15 rods prepared in this study demonstrate higher adsorption capacity towards large protein molecules such as bovine serum albumin and lysozyme, and enhanced cellular uptake efficiency in human osteosarcoma cancer cells. This novel silica material with small particle sizes, large pores as well as excellent biocompatibility is a promising delivery system for the cellular delivery of large molecular weight therapeutic agents with improved efficacy. This journal is
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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