Epigenetic modification: possible approach to reduce Salmonella enterica serovar enteritidis susceptibility under stress conditions

Soleimani, A. F., Zulkifli, I., Hair-Bejo, M., Ebrahimi, M., Jazayeri, S. D., Hashemi, S. R., Meimandipour, A. and Goh, Y. M. (2012) Epigenetic modification: possible approach to reduce Salmonella enterica serovar enteritidis susceptibility under stress conditions. Avian Pathology, 41 4: 351-354. doi:10.1080/03079457.2012.691155


Author Soleimani, A. F.
Zulkifli, I.
Hair-Bejo, M.
Ebrahimi, M.
Jazayeri, S. D.
Hashemi, S. R.
Meimandipour, A.
Goh, Y. M.
Title Epigenetic modification: possible approach to reduce Salmonella enterica serovar enteritidis susceptibility under stress conditions
Journal name Avian Pathology   Check publisher's open access policy
ISSN 0307-9457
1465-3338
Publication date 2012-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1080/03079457.2012.691155
Volume 41
Issue 4
Start page 351
End page 354
Total pages 4
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor and Francis
Collection year 2012
Language eng
Subject 1103 Clinical Sciences
3403 Food Animals
2400 Immunology and Microbiology
Abstract Stressors may influence chicken susceptibility to pathogens such as Salmonella enterica. Feed withdrawal stress can cause changes in normal intestinal epithelial structure and may lead to increased attachment and colonization of Salmonella. This study aimed to investigate modulatory effects of epigenetic modification by feed restriction on S. enterica serovar Enteritidis colonization in broiler chickens subjected to feed withdrawal stress. Chicks were divided into four groups: ad libitum feeding; ad libitum feeding with 24-h feed withdrawal on day 42; 60% feed restriction on days 4, 5, and 6; and 60% feed restriction on days 4, 5, and 6 with 24-h feed withdrawal on day 42. Attachment of S. Enteritidis to ileal tissue was determined using an ex vivo ileal loop assay, and heat shock protein 70 (Hsp70) expression was evaluated using sodium dodecyl sulphate-polyacrylamide gel electrophoresis and western blotting. Feed withdrawal stress increased S. Enteritidis attachment to ileal tissue. However, following feed withdrawal the epigenetically modified chickens had significantly lower attachment of S. Enteritidis than their control counterparts. A similar trend with a very positive correlation was observed for Hsp70 expression. It appears that epigenetic modification can enhance resistance to S. Enteritidis colonization later in life in chickens under stress conditions. The underlying mechanism could be associated with the lower Hsp70 expression in the epigenetically modified chickens.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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