Thermally chitosan/orthophosphate gelling system

Ta, Thu-Hang and Dunstan, David (2006). Thermally chitosan/orthophosphate gelling system. In: 25th Australian Colloid and Surface Science Student Conference: Program and Abstracts. 25ACSSSC: 25th Australian Colloid and Surface Science Student Conference, Beechworth, VIC, Australia, (86-86). 6-10 February, 2006.

Author Ta, Thu-Hang
Dunstan, David
Title of paper Thermally chitosan/orthophosphate gelling system
Conference name 25ACSSSC: 25th Australian Colloid and Surface Science Student Conference
Conference location Beechworth, VIC, Australia
Conference dates 6-10 February, 2006
Proceedings title 25th Australian Colloid and Surface Science Student Conference: Program and Abstracts
Place of Publication Beechworth, VIC, Australia
Publisher The University of Melbourne
Publication Year 2006
Sub-type Published abstract
Open Access Status
Start page 86
End page 86
Total pages 1
Language eng
Formatted Abstract/Summary
Directed drug and vaccine delivery has a number of significant advantages over general administration. Controlled delivery allows reduced levels of drug to be administered for similar efficacy. In summary, controlled delivery has both improved patient outcomes and significant economic benefits in reduced drug requirements.

Several different methods have been researched to control directed delivery. A thermally gelling biopolymer system such as chitosan linked with orthophosphate is found to be liquid at room temperature and gelled at body temperature. The molar ratio of chitosan to orthophosphate significantly affects gelling temperature of the system. The lower the ratio, the lower the gelling temperature.

Different molecular weights of chitosan macromolecules also influence the gelling temperature of the cross-linking system. Medium and high molecular weight chitosan exhibits higher gelling temperature than low molecular weight chitosan. However, among low molecular weight chitosan solutions, the lower the molecular weight, the higher the gelling temperature.

The outcome of this study is crucial in optimising the chitosan gelling system which will be applied as a delivery system for drugs and vaccines.
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Also known as "Thermo-sensitive chitosan/orthophosphate gel system". Presented as Poster #31.

 
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Created: Fri, 25 Jul 2014, 16:12:24 EST by Hang Ta on behalf of Aust Institute for Bioengineering & Nanotechnology