Correlation of loss of heterozygosity at 11p with tumour progression and survival in non-small cell lung cancer

Fong, Kwun M., Zimmerman, Paul V. and Smith, Peter J. (1994) Correlation of loss of heterozygosity at 11p with tumour progression and survival in non-small cell lung cancer. Genes Chromosomes and Cancer, 10 3: 183-189. doi:10.1002/gcc.2870100306


Author Fong, Kwun M.
Zimmerman, Paul V.
Smith, Peter J.
Title Correlation of loss of heterozygosity at 11p with tumour progression and survival in non-small cell lung cancer
Journal name Genes Chromosomes and Cancer   Check publisher's open access policy
ISSN 1045-2257
1098-2264
Publication date 1994-07
Sub-type Article (original research)
DOI 10.1002/gcc.2870100306
Open Access Status
Volume 10
Issue 3
Start page 183
End page 189
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Loss of heterozygosity (LOH) affecting loci at 11 p 13 and 11 p 15 occurs in childhood and adult carcinomas, including non-small cell lund cancer (NSCLC). In NSCLC, the highest reported frequency of LOH was 72% at the 11 p 13 catalase (CAT) locus. As this locus is centromeric to the Wilms' tumour (WTI) locus, possible involvement of WTI in the pathogenesis of NSCLC was considered. We thus examined 101 cases of NSCLC for LOH at the WTI and five other polymorphic loci along 11 p. At 11 p 13, the frequencies of LOH were 20% (9/46) at the FSHB locus, 9% (5/53) at the WTI locus, and 15% (6/41) at the CAT locus. The shortest region of overlap (SRO) at 11p13 was mapped centromeric to, but excluding, the WTI locus. Only adenocarcinomas showed LOH in this region. At 11 p 15, LOH affected 23% (18/77) of informative cases, with the highest frequency of 36% at the insulin (INS) locus. The SRO at 11 p15 was mapped telomeric to the RRMI locus. A third region, at 11 p13–15 between WTI and RRMI, was also affected by LOH. LOH at 11p correlated significantly with advanced T stage and nodal involvement in NSCLC tumours. In the squamous cell carcinoma subtype, LOH along 11p also correlated with nodal involvement. Furthermore, squamous tumours with LOH involving 11p13 loci had significantly worse survival than those without LOH. These data suggest that tumor suppressor gene(s) on 11p affect the progression of NSCLC, particularly squamous cell carcinomas.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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