Gender differences in autoimmune disease

Ngo, S. T., Steyn, F. J. and McCombe, P. A. (2014) Gender differences in autoimmune disease. Frontiers in Neuroendocrinology, 35 3: 347-369. doi:10.1016/j.yfrne.2014.04.004


Author Ngo, S. T.
Steyn, F. J.
McCombe, P. A.
Title Gender differences in autoimmune disease
Journal name Frontiers in Neuroendocrinology   Check publisher's open access policy
ISSN 1095-6808
0091-3022
Publication date 2014-08-01
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.yfrne.2014.04.004
Open Access Status DOI
Volume 35
Issue 3
Start page 347
End page 369
Total pages 23
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2015
Language eng
Abstract Autoimmune diseases are a range of diseases in which the immune response to self-antigens results in damage or dysfunction of tissues. Autoimmune diseases can be systemic or can affect specific organs or body systems. For most autoimmune diseases there is a clear sex difference in prevalence, whereby females are generally more frequently affected than males. In this review, we consider gender differences in systemic and organ-specific autoimmune diseases, and we summarize human data that outlines the prevalence of common autoimmune diseases specific to adult males and females in countries commonly surveyed. We discuss possible mechanisms for sex specific differences including gender differences in immune response and organ vulnerability, reproductive capacity including pregnancy, sex hormones, genetic predisposition, parental inheritance, and epigenetics. Evidence demonstrates that gender has a significant influence on the development of autoimmune disease. Thus, considerations of gender should be at the forefront of all studies that attempt to define mechanisms that underpin autoimmune disease.
Keyword Autoimmunity
Gender
Sex differences
Immune system
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2015 Collection
School of Biomedical Sciences Publications
School of Medicine Publications
 
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