Advances in IBD genetics

Van Limbergen, Johan, Radford-Smith, Graham and Satsangi, Jack (2014) Advances in IBD genetics. Nature Reviews Gastroenterology and Hepatology, 11 6: 372-385. doi:10.1038/nrgastro.2014.27

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Author Van Limbergen, Johan
Radford-Smith, Graham
Satsangi, Jack
Title Advances in IBD genetics
Journal name Nature Reviews Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 1759-5053
1759-5045
Publication date 2014-06
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrgastro.2014.27
Open Access Status
Volume 11
Issue 6
Start page 372
End page 385
Total pages 14
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2015
Language eng
Abstract IBD is a spectrum of chronic disorders that constitute an important health problem worldwide. The hunt for genetic determinants of disease onset and course has culminated in the Immunochip project, which has identified >160 loci containing IBD susceptibility genes. In this Review, we highlight how genetic association studies have informed our understanding of the pathogenesis of IBD by focusing research efforts on key pathways involved in innate immunity, autophagy, lymphocyte differentiation and chemotaxis. Several of these novel genetic markers and cellular pathways are promising candidates for patient stratification and therapeutic targeting.
Keyword IBD
Genetics
Genetic association studies
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 33 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 45 times in Scopus Article | Citations
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