Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro

Stephenson, Rachel, Varamini, Pegah, Butcher, Neville, Minchin, Rodney and Toth, Istvan (2014) Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro. Nanomedicine: Nanotechnology, Biology and Medicine, 10 8: 1799-1808. doi:10.1016/j.nano.2014.06.015

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Author Stephenson, Rachel
Varamini, Pegah
Butcher, Neville
Minchin, Rodney
Toth, Istvan
Title Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro
Formatted title
Effect of lipidated gonadotropin-releasing hormone peptides on receptor mediated binding and uptake into prostate cancer cells in vitro
Journal name Nanomedicine: Nanotechnology, Biology and Medicine   Check publisher's open access policy
ISSN 1549-9634
1549-9642
Publication date 2014-07
Sub-type Article (original research)
DOI 10.1016/j.nano.2014.06.015
Open Access Status
Volume 10
Issue 8
Start page 1799
End page 1808
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2015
Language eng
Formatted abstract
Gonadotropin-releasing hormone (GnRH) receptors are overexpressed on many cancer cells but not on primary cell lines. This study was designed to investigate the targeting ability and uptake of dendritic lipidated [Gln1]-GnRH peptide analogues on receptor-positive prostate cancer PC-3 cells relative to receptor-negative ovarian carcinoma SKOV-3 cells for potential application in drug delivery. Direct antiproliferative effect of these was investigated on three GnRH-receptor positive cancer cells, PC-3, LNCaP and DU145. A significant dose dependent growth inhibitory effect was produced in DU145 cells by 5 dendrimers giving an IC50 value of 22–35 μM. All compounds were non-toxic to the normal peripheral blood mononuclear cells.
Keyword Gonadotropin-releasing hormone
Lipoamino acid
Prostate cancer
Solid phase peptide synthesis
Targeting
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 8 July 2014

 
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Created: Fri, 18 Jul 2014, 09:31:39 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences