Mild anaemia is associated with increased all-cause mortality in heart failure

Teng, Tiew-Hwa Katherine, Finn, Judith and Hung, Joseph (2010) Mild anaemia is associated with increased all-cause mortality in heart failure. Heart, Lung and Circulation, 19 1: 31-37. doi:10.1016/j.hlc.2009.08.004

Author Teng, Tiew-Hwa Katherine
Finn, Judith
Hung, Joseph
Title Mild anaemia is associated with increased all-cause mortality in heart failure
Journal name Heart, Lung and Circulation   Check publisher's open access policy
ISSN 1443-9506
Publication date 2010-01
Sub-type Article (original research)
DOI 10.1016/j.hlc.2009.08.004
Open Access Status
Volume 19
Issue 1
Start page 31
End page 37
Total pages 7
Place of publication Chatswood, NSW, Australia
Publisher Elsevier
Language eng
Formatted abstract
Aim: To evaluate the association of anaemia with increased long-term morbidity and mortality in hospitalised heart failure (HF) patients.

Methods and results: We analysed medical records of a random sample of 1000 patients admitted to tertiary care hospitals from 1996 to 2006 with a principal diagnosis of HF. Anaemia (WHO criteria) on admission was present in 45.2% of HF patients. Multivariate analysis identified anaemia as an independent predictor of 5-year mortality with a hazard ratio (HR) of 1.44 (95%CI 1.20–1.73) compared to non-anaemic patients, and a rate ratio of 1.85 (95%CI 1.72–2.02) for unplanned all-cause readmission and 1.22 (95%CI 1.16–1.29) for HF readmission within 5 years. Compared to patients in the highest gender-specific Hb quartile, those with mild anaemia (Hb 11.3–13.0 g/dL in males, 11.0–12.4 g/dL in females) had an adjusted HR of 1.32 (95%CI 1.01–1.71) for 5-year mortality. Anaemia and chronic kidney disease were independent (additive) predictors of survival, whereas anaemia interacted with prevalent diabetes (p for interaction = 0.006), such that patients with both conditions had an adjusted mortality HR of 2.18 (95%CI 1.48–3.22) compared to those with diabetes only.

Conclusion: Mild anaemia is common in hospitalised HF patients and is an independent predictor of 5-year all-cause mortality in HF. 
Keyword Anaemia
Heart failure
Risk factors
Survival analysi
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Nursing, Midwifery and Social Work Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 17 Jul 2014, 13:47:11 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work