IL28B polymorphisms and treatment of hepatitis C

Clark, Paul J., Thompson, Alexander J. V. and Muir, Andrew J. (2011) IL28B polymorphisms and treatment of hepatitis C. Current Hepatitis Reports, 10 1: 70-78. doi:10.1007/s11901-010-0061-3


Author Clark, Paul J.
Thompson, Alexander J. V.
Muir, Andrew J.
Title IL28B polymorphisms and treatment of hepatitis C
Journal name Current Hepatitis Reports   Check publisher's open access policy
ISSN 1540-3416
1541-0706
Publication date 2011
Year available 2011
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11901-010-0061-3
Open Access Status
Volume 10
Issue 1
Start page 70
End page 78
Total pages 9
Place of publication Philadelphia, PA United States
Publisher Springer Healthcare
Collection year 2012
Language eng
Subject 2721 Hepatology
2406 Virology
Abstract Recently, single-nucleotide polymorphisms near the IL28B gene have been identified as important in predicting treatment response and spontaneous clearance of the hepatitis C virus (HCV). In the less than 12 months since the initial genetic discoveries, our knowledge base has rapidly expanded regarding the significance of the IL28B polymorphism in a variety of clinical settings. For genotype 1 HCV infection, it is clear that IL28B genotype has an important role in the prediction of treatment-induced and spontaneous clearance. This association remains important in the HIV/HCV-coinfected population. Host genotype adds further discriminatory information in HCV genotype 2/3 infection. IL28B genotype may remain significant with direct-acting antiviral therapy, although further studies are needed for antiviral agents and novel immunotherapy. Information on IL28B genotype improves treatment prediction with standard of care and will integrate with existing pretreatment clinical factors and measures of on-treatment response. Pretreatment knowledge of sustained viral response may help to reshape treatment regimens of the future with the possibility of reducing therapy duration and improving tolerability, safety, and efficacy.
Keyword Genome wide association analysis
Hepatitis C virus
Single nucleotide polymorphism (SNP)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Thu, 17 Jul 2014, 09:16:41 EST by Anthony Yeates on behalf of Medicine - Princess Alexandra Hospital