Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes)

Undheim, Eivind, Jones, Alun, Clauser, Karl R., Holland, John W., Pineda Gonzalez, Sandy, King, Glenn F and Bryan Fry (2014) Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes). Molecular Biology and Evolution, 31 8: 2124-2148. doi:10.1093/molbev/msu162


Author Undheim, Eivind
Jones, Alun
Clauser, Karl R.
Holland, John W.
Pineda Gonzalez, Sandy
King, Glenn F
Bryan Fry
Title Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (Centipedes)
Journal name Molecular Biology and Evolution   Check publisher's open access policy
ISSN 0737-4038
1537-1719
Publication date 2014-08
Year available 2014
Sub-type Article (original research)
DOI 10.1093/molbev/msu162
Open Access Status
Volume 31
Issue 8
Start page 2124
End page 2148
Total pages 25
Place of publication Cary United States
Publisher Oxford University Press
Collection year 2015
Language eng
Formatted abstract
Despite the staggering diversity of venomous animals, there seems to be remarkable convergence in regard to the types of proteins used as toxin scaffolds. However, our understanding of this fascinating area of evolution has been hampered by the narrow taxonomical range studied, with entire groups of venomous animals remaining almost completely unstudied. One such group is centipedes, class Chilopoda, which emerged about 440 Ma and may represent the oldest terrestrial venomous lineage next to scorpions. Here, we provide the first comprehensive insight into the chilopod “venome” and its evolution, which has revealed novel and convergent toxin recruitments as well as entirely new toxin families among both high- and low molecular weight venom components. The ancient evolutionary history of centipedes is also apparent from the differences between the Scolopendromorpha and Scutigeromorpha venoms, which diverged over 430 Ma, and appear to employ substantially different venom strategies. The presence of a wide range of novel proteins and peptides in centipede venoms highlights these animals as a rich source of novel bioactive molecules. Understanding the evolutionary processes behind these ancient venom systems will not only broaden our understanding of which traits make proteins and peptides amenable to neofunctionalization but it may also aid in directing bioprospecting efforts.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Biological Sciences Publications
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 21 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
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Created: Wed, 16 Jul 2014, 14:39:15 EST by Susan Allen on behalf of Institute for Molecular Bioscience