Association between in-vitro fertilization, birth and melanoma

Stewart, Louise M., Holman, C. D’Arcy J., Finn, Judith, Preen David B. and Hart, Roger (2013) Association between in-vitro fertilization, birth and melanoma. Melanoma Research, 23 6: 489-495. doi:10.1097/CMR.0000000000000019

Author Stewart, Louise M.
Holman, C. D’Arcy J.
Finn, Judith
Preen David B.
Hart, Roger
Title Association between in-vitro fertilization, birth and melanoma
Journal name Melanoma Research   Check publisher's open access policy
ISSN 0960-8931
Publication date 2013-12
Sub-type Article (original research)
DOI 10.1097/CMR.0000000000000019
Open Access Status
Volume 23
Issue 6
Start page 489
End page 495
Total pages 7
Place of publication Philadelphia, United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract A link between reproductive hormones and melanoma has long been suspected, and has been examined for numerous hormonal exposures, but the association between in-vitro fertilization (IVF) and melanoma has not been studied in depth. We used whole-population linked hospital and registry data to carry out a cohort study of women aged 20–44 years seeking hospital investigation and treatment for infertility in Western Australia from 1982 to 2002 with follow-up to 2010. The cohort comprised a total of 21 604 women followed for an average of 17.2 years. Of these, 7524 had IVF treatment, 14 870 gave birth and 149 women were diagnosed with an incident invasive melanoma. Using Cox regression analysis, we estimated hazard ratios (HRs) for melanoma associated with IVF and parity. Women who had IVF and gave birth had an increased rate of invasive melanoma compared with women who had IVF and remained nulliparous (HR 3.61; 95% confidence interval 1.79–7.26). There was little or no increase in the rate of invasive melanoma associated with giving birth in women who had non-IVF infertility treatment (HR 1.39; 95% confidence interval 0.88–2.20). These results suggest an association between reproductive factors and melanoma in the subgroup of women undergoing IVF treatment.
Keyword Birth
Cohort studies
In-vitro fertilization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Nursing, Midwifery and Social Work Publications
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Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 15 Jul 2014, 10:31:55 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work