In vitro fertilization is associated with an increased risk of borderline ovarian tumours

Stewart, Louise M., Holman, C D'Arcy J., Finn, Judith, Preen, David B. and Hart, Roger (2013) In vitro fertilization is associated with an increased risk of borderline ovarian tumours. Gynecologic Oncology, 129 2: 372-376. doi:10.1016/j.ygyno.2013.01.027

Author Stewart, Louise M.
Holman, C D'Arcy J.
Finn, Judith
Preen, David B.
Hart, Roger
Title In vitro fertilization is associated with an increased risk of borderline ovarian tumours
Journal name Gynecologic Oncology   Check publisher's open access policy
ISSN 0090-8258
Publication date 2013-05
Sub-type Article (original research)
DOI 10.1016/j.ygyno.2013.01.027
Open Access Status
Volume 129
Issue 2
Start page 372
End page 376
Total pages 5
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
Objectives: To compare the risk of borderline ovarian tumours in women having in vitro fertilization (IVF) with women diagnosed with infertility but not having IVF.

Methods: This was a whole-population cohort study of women aged 20–44 years seeking hospital infertility treatment or investigation in Western Australia in 1982–2002. Using Cox regression, we examined the effects of IVF treatment and potential confounders on the rate of borderline ovarian tumours. Potential confounders included parity, age, calendar year, socio-economic status, infertility diagnoses including pelvic inflammatory disorders and endometriosis and surgical procedures including hysterectomy and tubal ligation.

Results: Women undergoing IVF had an increased rate of borderline ovarian tumours with a hazard ratio (HR) of 2.46 (95% confidence interval [CI] 1.20–5.04). Unlike invasive epithelial ovarian cancer, neither birth (HR 0.89; 95% CI 0.43–1.88) nor hysterectomy (1.02; 0.24–4.37) nor sterilization (1.48; 0.63–3.48) appeared protective and the rate was not increased in women with a diagnosis of endometriosis (HR 0.31; 95% CI 0.04–2.29).

Conclusions: Women undergoing IVF treatment are at increased risk of being diagnosed with borderline ovarian tumours. Risk factors for borderline ovarian tumours appear different from those for invasive ovarian cancer. 
Keyword In vitro fertilization
Borderline ovarian tumours
Cohort study
Hazard ratios
Risk factors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Nursing, Midwifery and Social Work Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 15 Jul 2014, 10:00:10 EST by Vicki Percival on behalf of School of Nursing, Midwifery and Social Work