Prospective memory impairment in long-term opiate users

Terrett, Gill, McLennan, Skye N., Henry, Julie D., Biernacki, Kathryn, Mercuri, Kimberly, Curran, H. Valerie and Rendell, Peter G. (2014) Prospective memory impairment in long-term opiate users. Psychopharmacology, 231 13: 2623-2632. doi:10.1007/s00213-014-3432-6

Author Terrett, Gill
McLennan, Skye N.
Henry, Julie D.
Biernacki, Kathryn
Mercuri, Kimberly
Curran, H. Valerie
Rendell, Peter G.
Title Prospective memory impairment in long-term opiate users
Journal name Psychopharmacology   Check publisher's open access policy
ISSN 1432-2072
Publication date 2014-07
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s00213-014-3432-6
Open Access Status
Volume 231
Issue 13
Start page 2623
End page 2632
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2015
Language eng
Formatted abstract
Opiate use is associated with a range of neurological and cognitive deficits. However, to date, no studies have assessed whether these cognitive deficits extend to the ability to perform intended actions in the future (i.e. prospective memory). Reduced ability in this area might be anticipated due to impaired executive functions and episodic memory associated with long-term opiate use.

The main objectives of this study are to assess the performance of long-term opiate users on a laboratory measure of prospective memory which closely simulates the types of prospective memory tasks encountered in everyday life (‘Virtual Week’) and to investigate the extent to which prospective memory performance is related to executive functions and episodic memory ability.

Twenty-six long-term heroin users enrolled in an opiate substitution program, and 30 controls with no previous history of drug use were tested on Virtual Week. Retrospective memory and executive functions were also assessed.

Long-term opiate users were significantly impaired on prospective memory performance compared with controls (p = 0.002, η2 p = 0.17), and these deficits did not vary as a function of prospective memory task type (regular, irregular, event, time). The findings also suggest that retrospective memory difficulties contribute to the prospective memory difficulties seen in opiate users (r s  = 0.78, p < 0.001) but that executive dysfunction is less influential.

Prospective memory is sensitive to long-term opiate use. Importantly, opiate users suffer from generalised deficits in prospective memory, regardless of the task demands, which may have significant implications for day-to-day functioning. These results may therefore contribute to the development of clinical intervention strategies to reduce the negative impact of prospective memory failures in daily life.
Keyword Prospective memory
Opiate users
Virtual Week
Executive functions
Retrospective memory
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Psychology Publications
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Created: Tue, 15 Jul 2014, 03:09:04 EST by System User on behalf of School of Psychology