Peptide dose and/or structure in vaccines as a determinant of T cell responses

Leggatt, Graham R. (2014) Peptide dose and/or structure in vaccines as a determinant of T cell responses. Vaccines, 2 3: 537-548. doi:10.3390/vaccines2030537

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Author Leggatt, Graham R.
Title Peptide dose and/or structure in vaccines as a determinant of T cell responses
Journal name Vaccines   Check publisher's open access policy
ISSN 2076-393X
Publication date 2014-09
Sub-type Article (original research)
DOI 10.3390/vaccines2030537
Open Access Status DOI
Volume 2
Issue 3
Start page 537
End page 548
Total pages 12
Place of publication Basel, Switzerland
Publisher M D P I
Collection year 2015
Language eng
Formatted abstract
While T cells recognise the complex of peptide and major histocompatibility complex (MHC) at the cell surface, changes in the dose and/or structure of the peptide component can have profound effects on T cell activation and function. In addition, the repertoire of T cells capable of responding to any given peptide is variable, but broader than a single clone. Consequently, peptide parameters that affect the interaction between T cells and peptide/MHC have been shown to select particular T cell clones for expansion and this impacts on clearance of disease. T cells with high functional avidity are selected on low doses of peptide, while low avidity T cells are favoured in high peptide concentrations. Altering the structure of the peptide ligand can also influence the selection and function of peptide-specific T cell clones. In this review, we will explore the evidence that the choice of peptide dose or the structure of the peptide are critical parameters in an effective vaccine designed to activate T cells.
Keyword Vaccination
T cell avidity
Altered peptide ligands
Peptide dose
Peptide structure
Peptide vaccines
Functional avidity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
UQ Diamantina Institute Publications
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Created: Fri, 04 Jul 2014, 17:02:24 EST by Dr Graham Leggatt on behalf of UQ Diamantina Institute