Nervous translation, do you get the message? A review of mRNPs, mRNA-protein interactions and translational control within cells of the nervous system

Smith, Ross, Rathod, Reena Jagdish, Rajkumar, Shalini and Kennedy, Derek (2014) Nervous translation, do you get the message? A review of mRNPs, mRNA-protein interactions and translational control within cells of the nervous system. Cellular and Molecular Life Sciences, 71 20: 3917-3937. doi:10.1007/s00018-014-1660-x

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Author Smith, Ross
Rathod, Reena Jagdish
Rajkumar, Shalini
Kennedy, Derek
Title Nervous translation, do you get the message? A review of mRNPs, mRNA-protein interactions and translational control within cells of the nervous system
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
1420-9071
Publication date 2014-06-22
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s00018-014-1660-x
Open Access Status
Volume 71
Issue 20
Start page 3917
End page 3937
Total pages 21
Place of publication Basel, Switzerland
Publisher Birkhaeuser Science
Collection year 2015
Language eng
Formatted abstract
In neurons, translation of a message RNA can occur metres away from its transcriptional origin and in normal cells this is orchestrated with perfection. The life of an mRNA will see it pass through multiple steps of processing in the nucleus and the cytoplasm before it reaches its final destination. Processing of mRNA is determined by a myriad of RNA-binding proteins in multi-protein complexes called messenger ribonucleoproteins; however, incorrect processing and delivery of mRNA can cause several human neurological disorders. This review takes us through the life of mRNA from the nucleus to its point of translation in the cytoplasm. The review looks at the various cis and trans factors that act on the mRNA and discusses their roles in different cells of the nervous system and human disorders.
Keyword mRNP
mRNA transport
Nucleocytoplasmic-shuttling
Translational control
Survival of motor neuron
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 22 June 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
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Created: Fri, 27 Jun 2014, 14:21:25 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences