Metallo-beta-lactamases and their biomimetic complexes

Daumann, Lena J., Schenk, Gerhard and Gahan, Lawrence R. (2014) Metallo-beta-lactamases and their biomimetic complexes. European Journal of Inorganic Chemistry, 2014 18: 2869-2885. doi:10.1002/ejic.201402203


Author Daumann, Lena J.
Schenk, Gerhard
Gahan, Lawrence R.
Title Metallo-beta-lactamases and their biomimetic complexes
Formatted title
Metallo-β-lactamases and their biomimetic complexes
Journal name European Journal of Inorganic Chemistry   Check publisher's open access policy
ISSN 1434-1948
1099-0682
Publication date 2014-06
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/ejic.201402203
Open Access Status
Volume 2014
Issue 18
Start page 2869
End page 2885
Total pages 17
Place of publication Weinheim, Germany
Publisher Wiley - V C H Verlag
Collection year 2015
Language eng
Formatted abstract
In order to treat bacterial infections successfully in the future, the mechanism of action of metallo-β-lactamases (MβLs) needs to be fully understood so that clinically useful inhibitors and new therapeutic approaches can be developed. This microreview describes recent developments and the achievements towards the design of MβL biomimetics to aid in the mechanistic and structural understanding of these enzyme systems. We highlight the known inhibitors and substrates employed in these studies, the different ligands and complexes employed, and the experimental and computational studies undertaken to explore the possible mechanisms of action of the MβLs.
Keyword Metallo-β-lactamases
Biomimetics
Metalloenzymes
Enzyme models
Antibiotic resistance
Metallo-beta-lactamases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Fri, 27 Jun 2014, 11:57:54 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences