Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells

Arner, Erik, Forrest, Alistair R. R., Ehrlund, Anna, Mejhert, Niklas, Itoh, Masayoshi, Kawaji, Hideya, Lassman, Timo, Laurencikiene, Jurga, Ryden, Mikael, Arner, Peter and the FANTOM Consortium (2014) Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells. PLoS One, 9 3: . doi:10.1371/journal.pone.0080274

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Author Arner, Erik
Forrest, Alistair R. R.
Ehrlund, Anna
Mejhert, Niklas
Itoh, Masayoshi
Kawaji, Hideya
Lassman, Timo
Laurencikiene, Jurga
Ryden, Mikael
Arner, Peter
the FANTOM Consortium
Total Author Count Override 2772
Title Ceruloplasmin is a novel adipokine which is overexpressed in adipose tissue of obese subjects and in obesity-associated cancer cells
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2014-03-27
Year available 2014
Sub-type Article (original research)
DOI 10.1371/journal.pone.0080274
Open Access Status DOI
Volume 9
Issue 3
Total pages 5
Place of publication San Francisco, United States
Publisher Public Library of Science
Collection year 2015
Language eng
Abstract Obesity confers an increased risk of developing specific cancer forms. Although the mechanisms are unclear, increased fat cell secretion of specific proteins (adipokines) may promote/facilitate development of malignant tumors in obesity via cross-talk between adipose tissue(s) and the tissues prone to develop cancer among obese. We searched for novel adipokines that were overexpressed in adipose tissue of obese subjects as well as in tumor cells derived from cancers commonly associated with obesity. For this purpose expression data from human adipose tissue of obese and non-obese as well as from a large panel of human cancer cell lines and corresponding primary cells and tissues were explored. We found expression of ceruloplasmin to be the most enriched in obesity-associated cancer cells. This gene was also significantly up-regulated in adipose tissue of obese subjects. Ceruloplasmin is the body's main copper carrier and is involved in angiogenesis. We demonstrate that ceruloplasmin is a novel adipokine, which is produced and secreted at increased rates in obesity. In the obese state, adipose tissue contributed markedly (up to 22%) to the total circulating protein level. In summary, we have through bioinformatic screening identified ceruloplasmin as a novel adipokine with increased expression in adipose tissue of obese subjects as well as in cells from obesity-associated cancers. Whether there is a causal relationship between adipose overexpression of ceruloplasmin and cancer development in obesity cannot be answered by these cross-sectional comparisons.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Article number e80274

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 26 Jun 2014, 14:00:32 EST by Cathy Fouhy on behalf of Aust Institute for Bioengineering & Nanotechnology