Plasma metabolites associated with residual feed intake and other productivity performance traits in beef cattle

Karisa, B. K., Thomson, J., Wang, Z., Li, C., Montanholi, Y. R., Miller, S. P., Moore, S. S. and Plastow, G. S. (2014) Plasma metabolites associated with residual feed intake and other productivity performance traits in beef cattle. Livestock Science, 165 200-211. doi:10.1016/j.livsci.2014.03.002


Author Karisa, B. K.
Thomson, J.
Wang, Z.
Li, C.
Montanholi, Y. R.
Miller, S. P.
Moore, S. S.
Plastow, G. S.
Title Plasma metabolites associated with residual feed intake and other productivity performance traits in beef cattle
Journal name Livestock Science   Check publisher's open access policy
ISSN 1871-1413
Publication date 2014-07
Year available 2014
Sub-type Article (original research)
DOI 10.1016/j.livsci.2014.03.002
Open Access Status
Volume 165
Start page 200
End page 211
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Collection year 2015
Language eng
Abstract The objective of this study was to identify blood metabolites associated with variation primarily in residual feed intake (RFI) in two populations of beef steers at the University of Guelph and University of Alberta, Canada, representing the discovery and validation populations, respectively. Other productivity performance traits including average body weight (ABW), average feed intake (AFI), dry matter intake (DMI) and average daily gain (ADG) were also investigated. In the discovery population, blood plasma samples were obtained from 32 steers (16 high- and 16 low-RFI, from a population of 112 steers and maximizing the divergence between groups for RFI) at three periods 1, 2 and 3, corresponding to weeks 2, 6 and 10 respectively of the 140. d feeding and performance test. In the validation population, blood samples were obtained from 20 (10 high and 10 low RFI) steers from periods 1 and 2 corresponding to weeks 2 and 6 of a 90. d feeding test period. Metabolite concentrations in plasma were determined using nuclear magnetic resonance (NMR) and multiple regression analysis was performed in SAS 9.1. Creatine and glycine were associated (P<0.05) with RFI in period 1 accounting for 36.3% of the phenotypic variation in RFI. At period 2, threonine, carnitine, acetate, creatine, phenylalanine, lysine, citrate, betaine, glutamate and hippurate were significant (P<0.05) and accounted for 74.2% of the variation in RFI. At period 3, hydroxyisobutyrate, tyrosine and formate were significant (P<0.05) and accounted for 52.1% of the variation in RFI. In the validation population, three metabolites (creatine, carnitine and hippurate) were significant (P<0.05) in both discovery and validation populations and these three metabolites accounted for 32% of the phenotypic variation in RFI in the validation population. Some of the metabolites associated with RFI were also associated with other performance traits discussed in subsequent sections. Metabolic networks for RFI in each period were reconstructed using IPA and suggested that the biological processes associated with RFI were involved in energy and protein metabolism as well as metabolism of urea and methane. The analysis of metabolites and evaluation of biological processes create a better understanding of the metabolic processes that affect RFI. Upon further validation, these indicators may have potential to be utilized as biomarkers to enhance the selection of beef cattle.
Keyword Biomarker
Metabolic network
Metabolites
Residual feed intake
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Queensland Alliance for Agriculture and Food Innovation
 
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