Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport

Matusica, Dusan and Coulson, Elizabeth J. (2014) Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport. Seminars in Cell and Developmental Biology, 31 57-63. doi:10.1016/j.semcdb.2014.03.032


Author Matusica, Dusan
Coulson, Elizabeth J.
Title Local versus long-range neurotrophin receptor signalling: Endosomes are not just carriers for axonal transport
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1084-9521
1096-3634
Publication date 2014-07
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcdb.2014.03.032
Open Access Status DOI
Volume 31
Start page 57
End page 63
Total pages 7
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2015
Language eng
Subject 1309 Developmental Biology
1307 Cell Biology
Abstract Neurotrophins play a critical role in neuronal development and survival, as well as maintenance of the adult nervous system. Neurotrophins can mediate their effects by signalling locally at the nerve terminal, or signalling retrogradely from the axonal terminal to the cell soma to regulate gene expression. Given that the axon terminals of many nerve cells can be up to a metre away from their soma, neurons have evolved specialized long-range signalling platforms that depend on a highly regulated network of intracellular membrane compartments termed "signalling endosomes". Endosomal trafficking of activated receptors controls not only the axonal retrograde signals but also local receptor recycling and degradation. Endosomal trafficking involving the sorting and compartmentalizing of different signals, which are subsequently distributed to the appropriate cellular destination, can at least partially explain how neurotrophins generate a diverse array of signalling outcomes. Although signalling endosomes provide a useful model for understanding how different cell surface receptor-mediated signals are generated and transported, the precise role, identity and functional definition of a signalling endosome remains unclear. In this review we will discuss the regulation of local versus long-range neurotrophin signalling, with a specific focus on recent developments in the role of endosomes in regulating the fate of Trk receptors.
Keyword Endosome acidification
Membrane motility
Neurotrophins
Receptor internalization
Signalling endosome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
 
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