Review article: Associations between Helicobacter pylori and obesity - An ecological study

Lender, N., Talley, N. J., Enck, P., Haag, S., Zipfel, S., Morrison, M. and Holtmann, G. J. (2014) Review article: Associations between Helicobacter pylori and obesity - An ecological study. Alimentary Pharmacology and Therapeutics, 40 1: 24-31. doi:10.1111/apt.12790


Author Lender, N.
Talley, N. J.
Enck, P.
Haag, S.
Zipfel, S.
Morrison, M.
Holtmann, G. J.
Title Review article: Associations between Helicobacter pylori and obesity - An ecological study
Journal name Alimentary Pharmacology and Therapeutics   Check publisher's open access policy
ISSN 0269-2813
1365-2036
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/apt.12790
Open Access Status
Volume 40
Issue 1
Start page 24
End page 31
Total pages 8
Place of publication Chichester, West Sussex, United Kingdom
Publisher Blackwell Publishing Ltd
Collection year 2015
Language eng
Subject 2736 Pharmacology (medical)
Abstract Background There is emerging debate over the effect of Helicobacter pylori infection on body mass index (BMI). A recent study demonstrated that individuals who underwent H. pylori eradication developed significant weight gain as compared to subjects with untreated H. pylori colonisation. Aim To elucidate the association between H. pylori colonisation and the prevalence of overweight and obesity in developed countries. Methods The literature was searched for publications reporting data on H. pylori prevalence rates and obesity prevalence rates. Studies selected reported H. pylori prevalence in random population samples with sample sizes of more than 100 subjects in developed countries (GDP >25 000 US$/person/year). Corresponding BMI distributions for corresponding countries and regions were identified. Nonparametric tests were used to compare the association between H. pylori and overweight and obesity rates. Results Forty-nine studies with data from 10 European countries, Japan, the US and Australia were identified. The mean H. pylori rate was 44.1% (range 17-75%), the mean rates for obesity and overweight were 46.6 (±16)% and 14.2 (±8.9)%. The rate of obesity and overweight were inversely and significantly (r = 0.29, P < 0.001) correlated with the prevalence of H. pylori infection. Conclusions There is an inverse correlation between H. pylori prevalence and rate of overweight/obesity in countries of the developed world. Thus, the gradual decrease of the H. pylori colonisation that has been observed in recent decades (or factors associated with decrease of) could be causally related to the obesity endemic observed in the Western world.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Faculty of Medicine
School of Medicine Publications
UQ Diamantina Institute Publications
 
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