FISH mapping of the porcine NPY5 gene to chromosome 8p11

Törnsten, A., Wraith, A., Larhammar, D. and Chowdhary, B. P. (1998) FISH mapping of the porcine NPY5 gene to chromosome 8p11. Mammalian Genome, 9 3: 262-263. doi:10.1007/s003359900742


Author Törnsten, A.
Wraith, A.
Larhammar, D.
Chowdhary, B. P.
Title FISH mapping of the porcine NPY5 gene to chromosome 8p11
Formatted title
FISH mapping of the porcine NPY5 gene to chromosome 8p11
Journal name Mammalian Genome   Check publisher's open access policy
ISSN 0938-8990
1432-1777
Publication date 1998-03
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1007/s003359900742
Open Access Status
Volume 9
Issue 3
Start page 262
End page 263
Total pages 2
Place of publication New York, NY, United States
Publisher Springer New York
Language eng
Formatted abstract
Discussion: The NPY Y5 receptor has been postulated to be the Y-type `feeding' receptor. NPY peptide analogs known to elicit feeding have high affinity for the Y5 receptor, and the distribution of the receptor mRNA in brain also supports a role in the regula- tion of feeding. The Y5 receptor has been cloned in both rat and human [4,5]. The pig Y5 shows 85% amino acid and 82% nucleo- tide identity with human Y5 over the coding region. The localization of porcine NPY5 to pig Chr 8pl l is in agreement with previ- ous comparative mapping data [6], which show that porcine Chr 8 (SSC8) corresponds to human Chr 4 (HSA4). We found that the pig KIT and NPY5 genes are in close proximity to each other, mapping to 8p12 and 8p11, respectively (see Figs. 1 and 2). Hu- man NPY5 has hitherto not been precisely mapped on HSA4q. Nonetheless, its location can be indirectly deduced because it is located 23 kb from NPY1, which maps to 4g31-32 [4,7,8]. Thus, as compared with pigs, the human homologs of NPY5 and KIT (4g12) [9] are separated by a much larger distance.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: UQ Centre for Clinical Research Publications
 
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Created: Wed, 18 Jun 2014, 11:33:22 EST by Amanda W. Kijas on behalf of UQ Centre for Clinical Research