Switching on sex: transcriptional regulation of the testis-determining gene Sry

Larney, Christian, Bailey, Timothy L. and Koopman, Peter (2014) Switching on sex: transcriptional regulation of the testis-determining gene Sry. Development (Cambridge), 141 11: 2195-2205. doi:10.1242/dev.107052


Author Larney, Christian
Bailey, Timothy L.
Koopman, Peter
Title Switching on sex: transcriptional regulation of the testis-determining gene Sry
Formatted title
Switching on sex: transcriptional regulation of the testis-determining gene Sry
Journal name Development (Cambridge)   Check publisher's open access policy
ISSN 1477-9129
0950-1991
Publication date 2014-06
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1242/dev.107052
Open Access Status DOI
Volume 141
Issue 11
Start page 2195
End page 2205
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher Company of Biologists
Collection year 2015
Formatted abstract
Mammalian sex determination hinges on the development of ovaries or testes, with testis fate being triggered by the expression of the transcription factor sex-determining region Y (Sry). Reduced or delayed Sry expression impairs testis development, highlighting the importance of its accurate spatiotemporal regulation and implying a potential role for SRY dysregulation in human intersex disorders. Several epigenetic modifiers, transcription factors and kinases are implicated in regulating Sry transcription, but it remains unclear whether or how this farrago of factors acts co-ordinately. Here we review our current understanding of Sry regulation and provide a model that assembles all known regulators into three modules, each converging on a single transcription factor that binds to the Sry promoter. We also discuss potential future avenues for discovering the cis-elements and trans-factors required for Sry regulation.
Keyword Disorders of sex development
Sex determination
Sry
Testis development
Transcriptional regulation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
Institute for Molecular Bioscience - Publications
 
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