Large-scale genomics unveils the genetic architecture of psychiatric disorders

Gratten, Jacob, Wray, Naomi R., Keller, Matthew C. and Visscher, Peter M. (2014) Large-scale genomics unveils the genetic architecture of psychiatric disorders. Nature Neuroscience, 17 6: 782-790. doi:10.1038/nn.3708

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Author Gratten, Jacob
Wray, Naomi R.
Keller, Matthew C.
Visscher, Peter M.
Title Large-scale genomics unveils the genetic architecture of psychiatric disorders
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1546-1726
1097-6256
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nn.3708
Open Access Status File (Author Post-print)
Volume 17
Issue 6
Start page 782
End page 790
Total pages 9
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2015
Language eng
Subject 2800 Neuroscience
Abstract Family study results are consistent with genetic effects making substantial contributions to risk of psychiatric disorders such as schizophrenia, yet robust identification of specific genetic variants that explain variation in population risk had been disappointing until the advent of technologies that assay the entire genome in large samples. We highlight recent progress that has led to a better understanding of the number of risk variants in the population and the interaction of allele frequency and effect size. The emerging genetic architecture implies a large number of contributing loci (that is, a high genome-wide mutational target) and suggests that genetic risk of psychiatric disorders involves the combined effects of many common variants of small effect, as well as rare and de novo variants of large effect. The capture of a substantial proportion of genetic risk facilitates new study designs to investigate the combined effects of genes and the environment.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Queensland Brain Institute Publications
Official 2015 Collection
UQ Diamantina Institute Publications
 
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