A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in Australia

Liyanage, Surabhi S., Segelov, Eva, Malik, Aisha, Garland, Suzanne M., Tabrizi, Sepehr N., Cummins, Eleanor, Seale, Holly, Rahman, Bayzidur, Moa, Aye, Barbour, Andrew P., Crowe, Philip J. and Macintyre, C. Raina (2014) A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in Australia. Journal of Oncology, 2014 Article No. 236482: . doi:10.1155/2014/236482


Author Liyanage, Surabhi S.
Segelov, Eva
Malik, Aisha
Garland, Suzanne M.
Tabrizi, Sepehr N.
Cummins, Eleanor
Seale, Holly
Rahman, Bayzidur
Moa, Aye
Barbour, Andrew P.
Crowe, Philip J.
Macintyre, C. Raina
Title A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in Australia
Journal name Journal of Oncology   Check publisher's open access policy
ISSN 1687-8469
1687-8450
Publication date 2014
Year available 2014
Sub-type Article (original research)
DOI 10.1155/2014/236482
Open Access Status DOI
Volume 2014
Issue Article No. 236482
Total pages 7
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Collection year 2015
Language eng
Formatted abstract
Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100,000 (95% CI: 30–5500). All control specimens were negative for HPV. Significantly higher rates of smoking, other aerodigestive cancers, and mortality were seen among cases than controls. A pooled analysis of this study and the only other Australian case-control study found that 9/321 cases and 0/155 controls were positive for HPV. The pooled odds ratio for HPV being a risk factor for OSCC was 9.35 (95% CI: 0.47–190.33). Conclusion. Our results suggest that in this multifactorial cancer HPV may be an additional risk factor; although a larger, better powered study is needed.
Keyword Human papillomavirus
Oesophageal squamous cell carcinoma
Australia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article ID 236482

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
School of Medicine Publications
 
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