Influence of hydrothermal treatment on physicochemical properties and drug release of anti-inflammatory drugs of intercalated layered double hydroxide nanoparticles

Gu, Zi, Wu, Aihua, Li, Li and Xu, Zhi Ping (2014) Influence of hydrothermal treatment on physicochemical properties and drug release of anti-inflammatory drugs of intercalated layered double hydroxide nanoparticles. Pharmaceutics, 6 2: 235-248. doi:10.3390/pharmaceutics6020235


Author Gu, Zi
Wu, Aihua
Li, Li
Xu, Zhi Ping
Title Influence of hydrothermal treatment on physicochemical properties and drug release of anti-inflammatory drugs of intercalated layered double hydroxide nanoparticles
Journal name Pharmaceutics   Check publisher's open access policy
ISSN 1999-4923
Publication date 2014-05-22
Year available 2014
Sub-type Article (original research)
DOI 10.3390/pharmaceutics6020235
Open Access Status DOI
Volume 6
Issue 2
Start page 235
End page 248
Total pages 14
Place of publication Basel, Switzerland
Publisher MDPI AG
Collection year 2015
Language eng
Subject 3003 Pharmaceutical Science
Abstract The synthesis method of layered double hydroxides (LDHs) determines nanoparticles' performance in biomedical applications. In this study, hydrothermal treatment as an important synthesis technique has been examined for its influence on the physicochemical properties and the drug release rate from drug-containing LDHs. We synthesised MgAl-LDHs intercalated with non-steroidal anti-inflammatory drugs (i.e., naproxen, diclofenac and ibuprofen) using a co-precipitation method with or without hydrothermal treatment (150 °C, 4 h). After being hydrothermally treated, LDH-drug crystallites increased in particle size and crystallinity, but did not change in the interlayer anion orientation, gallery height and chemical composition. The drug release patterns of all studied LDH-drug hybrids were biphasic and sustained. LDHs loaded with diclofenac had a quicker drug release rate compared with those with naproxen and ibuprofen, and the drug release from the hydrothermally-treated LDH-drug was slower than the freshly precipitated LDH-drug. These results suggest that the drug release of LDH-drugs is influenced by the crystallite size of LDHs, which can be controlled by hydrothermal treatment, as well as by the drug molecular physicochemical properties.
Keyword Drug release
Hydrothermal treatment
Layered double hydroxides
Nonsteroidal anti-inflammatory drugs
Physicochemical properties
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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