Effects of magnesium deficiency - More than skin deep

Chandrasekaran, Navin Chandrakanth, Weir, Christopher, Alfraji, Sumaya, Grice, Jeff, Roberts, Michael S. and Barnard, Ross T. (2014) Effects of magnesium deficiency - More than skin deep. Experimental Biology and Medicine, 239 10: 1280-1291. doi:10.1177/1535370214537745

Author Chandrasekaran, Navin Chandrakanth
Weir, Christopher
Alfraji, Sumaya
Grice, Jeff
Roberts, Michael S.
Barnard, Ross T.
Title Effects of magnesium deficiency - More than skin deep
Journal name Experimental Biology and Medicine   Check publisher's open access policy
ISSN 1535-3702
Publication date 2014-06-13
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1177/1535370214537745
Open Access Status
Volume 239
Issue 10
Start page 1280
End page 1291
Total pages 12
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2015
Language eng
Formatted abstract
Dead Sea and magnesium salt therapy are two of the oldest forms of treatment for skin disease and several other disorders, supported by a body of largely anecdotal evidence. In this paper we review possible pathways for penetration of magnesium ions through the epidermis to reach the circulation, in turn replenishing cellular magnesium levels. We also discuss mechanisms for intercellular movement of magnesium ions and possible mechanisms for the interaction between magnesium ions and inflammatory mediators. Upon addition of magnesium ions in vitro, the expression of inflammatory mediators such as tumour necrosis factor α (TNFα) and nuclear factor κβ (NFκβ) is down regulated. Dysregulation of these and other inflammatory mediators has been linked to several inflammatory disorders, including asthma, arthritis, atherosclerosis and neuroinflammation.
Keyword Magnesium
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 13 June 2014

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Chemistry and Molecular Biosciences
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 3 times in Scopus Article | Citations
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Created: Mon, 16 Jun 2014, 15:04:11 EST by Professor Ross Barnard on behalf of School of Chemistry & Molecular Biosciences