Sentinel node biopsy and large (>= 3 cm) breast cancer

Beumer, Jesse D., Gill, Grantley, Campbell, Ian, Wetzig, Neil, Ung, Owen, Farshid, Gelareh, Uren, Roger, Stockler, Martin and Gebski, Val (2014) Sentinel node biopsy and large (>= 3 cm) breast cancer. Anz Journal of Surgery, 84 3: 117-120. doi:10.1111/ans.12139

Author Beumer, Jesse D.
Gill, Grantley
Campbell, Ian
Wetzig, Neil
Ung, Owen
Farshid, Gelareh
Uren, Roger
Stockler, Martin
Gebski, Val
Title Sentinel node biopsy and large (>= 3 cm) breast cancer
Journal name Anz Journal of Surgery   Check publisher's open access policy
ISSN 1445-1433
Publication date 2014-03
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/ans.12139
Open Access Status
Volume 84
Issue 3
Start page 117
End page 120
Total pages 4
Place of publication Richmond, VIC Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2015
Language eng
Formatted abstract
Background: Sentinel node biopsy is an accurate method for staging the axilla in early (small) breast cancers. However, data for the role of this technique for large breast cancers remain limited.

Method: From the Royal Adelaide Hospital Sentinel Node database and the SNAC trial database, 100 subjects were identified with clinically node negative, large (3 cm) primary breast cancer who had undergone sentinel node biopsy and immediate axillary clearance. The pathology results from the sentinel node and axillary specimens were analysed.

Results: Average tumour size was 3.91 cm (range 3–10 cm) and 65 of 100 cases had metastatic disease in the axillary nodes. A sentinel node was successfully identified in 93 out of 100 cases with an average of 1.75 sentinel nodes sampled. Sixty-two per cent (58 out of 93) were sentinel node positive and 43% (43 out of 100) had a positive non-sentinel node. The false negative rate following successful sentinel node identification was 4.9% (3 out of 61).

Conclusion: Sentinel node biopsy was an accurate tool for staging the axilla with a false negative rate comparable to that seen in small tumours. However, given the increased incidence of metastases with larger cancers, further prospective investigation is warranted.
Keyword Standard Axillary Treatment
breast neoplasm
Carcinoma ductal breast
Sentinel lymph node biopsy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
School of Public Health Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 4 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 12 Jun 2014, 10:08:21 EST by Ms Kate Rowe on behalf of School of Public Health