Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm

Smallwood, L., Allcock, R., Van Bockxmeer, F., Warrington, N., Palmer, L. J., Iacopetta, B., Golledge, J. and Norman, P. E. (2008) Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm. British Journal of Surgery, 95 10: 1239-1244. doi:10.1002/bjs.6345


Author Smallwood, L.
Allcock, R.
Van Bockxmeer, F.
Warrington, N.
Palmer, L. J.
Iacopetta, B.
Golledge, J.
Norman, P. E.
Title Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm
Journal name British Journal of Surgery   Check publisher's open access policy
ISSN 0007-1323
1365-2168
Publication date 2008
Year available 2008
Sub-type Article (original research)
DOI 10.1002/bjs.6345
Open Access Status
Volume 95
Issue 10
Start page 1239
End page 1244
Total pages 6
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley and Sons Ltd.
Collection year 2009
Language eng
Subject 2746 Surgery
2700 Medicine
Abstract Background: Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA. Methods: The -1562C > T and -1811A > T variants of the MMP-9 gene were genotyped in 678 men with an AAA (at least 30 mm in diameter) and 659 control subjects (aortic diameter 19-22 mm) recruited from a population-based trial of screening for AAA. Levels of MMP-9 were measured in a random subset of 300 cases and 84 controls. The association between genetic variants (including haplotypes) and AAA was assessed by multivariable logistic regression. Results: There was no association between the MMP-9-1562C > T (odds ratio (OR) 0.70 (95 per cent confidence interval (c.i.) 0.27 to 1.82))or-1811A>T(OR 0.71 (95 per cent c.i. 028 to 1.85)) genotypes, or the most common haplotype (OR 0.81 (95 per cent c.i. 0-62 to 1-05)) and AAA. The serum MMP-9 concentration was higher in cases than controls, and in minor allele carriers in cases and controls, although the differences were not statistically significant. Conclusion: In this study, the genetic tendency to higher levels of circulating MMP-9 was not associated with AAA. Copyright
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Tue, 10 Jun 2014, 16:33:07 EST by Kylie Hengst on behalf of UQ Diamantina Institute