Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

Gudbjartsson, Daniel F., Bjornsdottir, Unnur S., Halapi, Eve, Helgadottir, Anna, Sulem, Patrick, Jonsdottir, Gudrun M., Thorleifsson, Gudmar, Helgadottir, Hafdis, Steinthorsdottir, Valgerdur, Stefansson, Hreinn, Williams, Carolyn, Hui, Jennie, Beilby, John, Warrington, Nicole M., James, Alan, Palmer, Lyle J., Koppelman, Gerard H., Heinzmann, Andrea, Krueger, Marcus, Boezen, H. Marike, Wheatley, Amanda, Altmuller, Janine, Shin, Hyoung Doo, Uh, Soo-Taek, Cheong, Hyun Sub, Jonsdottir, Brynja, Gislason, David, Park, Choon-Sik, Rasmussen, Linda M., Porsbjerg, Celeste, Hansen, Jakob W., Backer, Vibeke, Werge, Thomas, Janson, Christer, Jonsson ,U.lla-Britt, Ng, Maggie C. Y., Chan, Juliana, So, Wing Yee, Ma, Ronald, Shah, Svati H., Granger, Christopher B., Quyyumi, Arshed A., Levey, Allan I., Vaccarino, Viola, Reilly, Muredach P., Rader, Daniel J., Williams, Michael J. A., Van Rij, Andre M., Jones, Gregory T., Trabetti, Elisabetta, Malerba, Giovanni, Pignatti, Pier Franco, Boner, Attilio, Pescollderungg, Lydia, Girelli, Domenico, Olivieri, Oliviero, Martinelli, Nicola, Ludviksson, Bjorn R., Ludviksdottir, Dora, Eyjolfsson, Gudmundur I., Arnar, David, Thorgeirsson, Gudmundur, Deichmann, Klaus, Thompson, Philip J., Wjst, Matthias, Hall, Ian P., Postma, Dirkje S., Gislason, Thorarinn, Gulcher, Jeffrey, Kong, Augustine, Jonsdottir, Ingileif, Thorsteinsdottir, Unnur and Stefansson, Kari (2009) Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics, 41 3: 342-347. doi:10.1038/ng.323


Author Gudbjartsson, Daniel F.
Bjornsdottir, Unnur S.
Halapi, Eve
Helgadottir, Anna
Sulem, Patrick
Jonsdottir, Gudrun M.
Thorleifsson, Gudmar
Helgadottir, Hafdis
Steinthorsdottir, Valgerdur
Stefansson, Hreinn
Williams, Carolyn
Hui, Jennie
Beilby, John
Warrington, Nicole M.
James, Alan
Palmer, Lyle J.
Koppelman, Gerard H.
Heinzmann, Andrea
Krueger, Marcus
Boezen, H. Marike
Wheatley, Amanda
Altmuller, Janine
Shin, Hyoung Doo
Uh, Soo-Taek
Cheong, Hyun Sub
Jonsdottir, Brynja
Gislason, David
Park, Choon-Sik
Rasmussen, Linda M.
Porsbjerg, Celeste
Hansen, Jakob W.
Backer, Vibeke
Werge, Thomas
Janson, Christer
Jonsson ,U.lla-Britt
Ng, Maggie C. Y.
Chan, Juliana
So, Wing Yee
Ma, Ronald
Shah, Svati H.
Granger, Christopher B.
Quyyumi, Arshed A.
Levey, Allan I.
Vaccarino, Viola
Reilly, Muredach P.
Rader, Daniel J.
Williams, Michael J. A.
Van Rij, Andre M.
Jones, Gregory T.
Trabetti, Elisabetta
Malerba, Giovanni
Pignatti, Pier Franco
Boner, Attilio
Pescollderungg, Lydia
Girelli, Domenico
Olivieri, Oliviero
Martinelli, Nicola
Ludviksson, Bjorn R.
Ludviksdottir, Dora
Eyjolfsson, Gudmundur I.
Arnar, David
Thorgeirsson, Gudmundur
Deichmann, Klaus
Thompson, Philip J.
Wjst, Matthias
Hall, Ian P.
Postma, Dirkje S.
Gislason, Thorarinn
Gulcher, Jeffrey
Kong, Augustine
Jonsdottir, Ingileif
Thorsteinsdottir, Unnur
Stefansson, Kari
Title Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1038/ng.323
Open Access Status
Volume 41
Issue 3
Start page 342
End page 347
Total pages 6
Place of publication New York, NY United States
Publisher Nature Publishing Group
Collection year 2010
Language eng
Subject 1311 Genetics
Abstract Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 × 10-14, 5.4 × 10 -10, 8.6 × 10-17, 1.2 × 10-10 and 6.5 × 10-19, respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 × 10-12) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 × 10-6, 2.2 × 10-5 and 2.4 × 10-4, respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 × 10 -8) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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