Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm

Golledge, Jonathan, Biros, Erik, Cooper, Matthew, Warrington, Nicole, Palmer, Lyle J. and Norman, Paul E. (2010) Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm. Atherosclerosis, 209 2: 487-491. doi:10.1016/j.atherosclerosis.2009.09.027


Author Golledge, Jonathan
Biros, Erik
Cooper, Matthew
Warrington, Nicole
Palmer, Lyle J.
Norman, Paul E.
Title Apolipoprotein E genotype is associated with serum C-reactive protein but not abdominal aortic aneurysm
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
1879-1484
Publication date 2010
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2009.09.027
Open Access Status
Volume 209
Issue 2
Start page 487
End page 491
Total pages 5
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland Ltd
Collection year 2011
Language eng
Subject 2705 Cardiology and Cardiovascular Medicine
Abstract Objective: Apolipoprotein E (ApoE) genotype has been associated with systemic inflammation and athero-thrombosis however the association with abdominal aortic aneurysm (AAA) has not been previously examined. We assessed the association between ApoE genotype with AAA presence and growth, and serum C-reactive protein (CRP). Methods: Serum concentrations of CRP (in 1358 men) and 6 single nucleotide polymorphisms (SNPs) for ApoE (in 1711 men) were examined in subjects from the Health In Men Study. 640 men with small AAAs were followed by ultrasound surveillance for a mean of 4.1 years. Results: There was no association between ApoE genotype and AAA presence. Men heterozygote for the ApoE p.Arg176Cys polymorphism had slower AAA growth, odds ratio for AAA progression ≥ median 0.41, 95% confidence intervals 0.21-0.80, p=0.01. Men heterozygote for the ApoE g.50093756A > G polymorphism had slightly more rapid AAA growth, odds ratio for AAA progression ≥ median 1.48, 95% confidence intervals 1.02-2.14, p=0.04. None of the ApoE SNPs were associated with AAA growth however taking into account multiple testing. Two SNPs in ApoE were associated with serum CRP under a co-dominant model, ApoE p.Cys130Arg (SNP ID rs429358), p=0.00003 and ApoE g.50114786A > G (SNP ID rs4420638), p=0.00013. Adjusting for other risk factors plus serum creatinine the e{open}4 allele was associated with lower serum CRP under a dominant model, coefficient 0.089, p=0.002. Conclusion: We found no consistent association between ApoE genotype and AAA. We confirmed an association between ApoE genotype and serum CRP.
Keyword Abdominal aortic aneurysm
Apolipoprotein E
Genotype
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Tue, 10 Jun 2014, 16:24:49 EST by Kylie Hengst on behalf of UQ Diamantina Institute