Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents

Skouen, J. S., Smith, A. J., Warrington, N. M., O'Sullivan, P. B., McKenzie, L., Pennell, C. E. and Straker, L. M. (2012) Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents. European Journal of Pain (United Kingdom), 16 9: 1232-1242. doi:10.1002/j.1532-2149.2012.00131.x


Author Skouen, J. S.
Smith, A. J.
Warrington, N. M.
O'Sullivan, P. B.
McKenzie, L.
Pennell, C. E.
Straker, L. M.
Title Genetic variation in the beta-2 adrenergic receptor is associated with chronic musculoskeletal complaints in adolescents
Journal name European Journal of Pain (United Kingdom)   Check publisher's open access policy
ISSN 1090-3801
1532-2149
Publication date 2012
Year available 2012
Sub-type Article (original research)
DOI 10.1002/j.1532-2149.2012.00131.x
Open Access Status
Volume 16
Issue 9
Start page 1232
End page 1242
Total pages 11
Place of publication Chichester, West Sussex, United Kingdom
Publisher John Wiley and Sons Ltd.
Collection year 2013
Language eng
Subject 2703 Anesthesiology and Pain Medicine
2700 Medicine
Abstract Background: There is significant evidence to suggest that psychological and stress-related factors are important predictors of the onset of chronic widespread pain (CWP) and fibromyalgia (FM). The hypothalamic-pituitary-adrenal axis, together with the efferent sympathetic/adrenomedullary system, influence all body organs (including muscles) during short- and long-term threatening stimuli. The aim of this study was to investigate the relationship between genetic variants in adrenergic candidate genes and chronic musculoskeletal complaints (MSCs) in adolescents. Methods: Adolescents from the Western Australian Pregnancy (Raine) Cohort attending the 17-year cohort review completed a questionnaire containing a broad range of psychosocial factors and pain assessment (n = 1004). Blood samples were collected for DNA extraction and genotyping. Genotype data was obtained for 14 single nucleotide polymorphisms (SNPs) in two candidate genes - beta-2 adrenergic receptor (ADRB2) and catecholamine-O-methyltransferase (COMT). Haplotypes were reconstructed for all individuals with genotype data. Results and Conclusion: Both female gender and poor mental health were associated with (1) an increased risk for chronic, disabling comorbid neck and low back pain (CDCP); and (2) an increase in the number of areas of pain. Of the 14 SNPs evaluated, only SNP rs2053044 (ADRB2, recessive model) displayed an association with CDCP [odds ratio (OR) = 2.49; 95% confidence interval (CI) = 1.25, 4.98; p = 0.01] and pain in three to four pain areas in the last month (OR = 1.86; 95% CI = 1.13, 3.06; p = 0.02). These data suggest that genetic variants in ADRB2 may be involved in chronic MSCs.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Tue, 10 Jun 2014, 15:23:09 EST by Kylie Hengst on behalf of UQ Diamantina Institute