Negative pigment network and shiny white streaks: a dermoscopic- pathological correlation study

Pizzichetta, Maria A., Canzonieri, Vincenzo, Soyer, Peter H., Rubegni, Pietro, Talamini, Renato and Massone, Cesare (2014) Negative pigment network and shiny white streaks: a dermoscopic- pathological correlation study. American Journal of Dermatopathology, 36 5: 433-438. doi:10.1097/DAD.0000000000000019


Author Pizzichetta, Maria A.
Canzonieri, Vincenzo
Soyer, Peter H.
Rubegni, Pietro
Talamini, Renato
Massone, Cesare
Title Negative pigment network and shiny white streaks: a dermoscopic- pathological correlation study
Journal name American Journal of Dermatopathology   Check publisher's open access policy
ISSN 0193-1091
1533-0311
Publication date 2014-01-01
Sub-type Article (original research)
DOI 10.1097/DAD.0000000000000019
Volume 36
Issue 5
Start page 433
End page 438
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams and Wilkins
Language eng
Abstract It has been suggested that both negative pigment network (NPN) and shiny white streaks (SWS) were related to an increase of dermal collagen. To study precisely the dermoscopic-histopathologic correlation of NPN and SWS, we have performed a dermoscopic-pathological correlation study. A total of 25 skin lesions dermoscopically characterized by the presence of NPN and/or SWS, including histopathologically confirmed dermatofibroma (2), Spitz nevus (3), compound nevus (6), dysplastic nevus (7), and melanoma (7), were evaluated for the presence of NPN, SWS, and blue-white veil. The histopathologic features such as orthokeratosis, orthokeratosis plus nests of pigmented melanocytes at the junction, hypergranulosis, hypergranulosis plus nests of pigmented melanocytes at the junction, epidermal invagination plus orthokeratosis, fibrosis, lamellar fibrosis, and elongation and bridging of rete ridges were evaluated. We found a disagreement in 80% of skin lesions between NPN and fibrosis (P = 0.02). For SWS, a significant agreement emerged with hypergranulosis (76%; P = 0.01), and the same occurred with fibrosis (80%; P = 0.01). Moreover, blue-white veil also displayed a significant agreement with hypergranulosis (68%; P = 0.04). Our findings confirm the correlation of SWS with fibrosis, whereas a clear-cut histopathologic substrate of NPN could not be established.
Keyword Dermatofibroma
Melanocytic nevi
Melanoma
Negative pigment network
Shiny white streaks
Spitz nevus
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Author post-print permissible

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2015 Collection
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