Blood from 'junk': the LTR chimeric transcript Pu.2 promotes erythropoiesis

Upton, Kyle R. and Faulkner,Geoffrey J. (2014) Blood from 'junk': the LTR chimeric transcript Pu.2 promotes erythropoiesis. Mobile DNA, 5 1: . doi:10.1186/1759-8753-5-15


Author Upton, Kyle R.
Faulkner,Geoffrey J.
Title Blood from 'junk': the LTR chimeric transcript Pu.2 promotes erythropoiesis
Formatted title
Blood from 'junk': the LTR chimeric transcript Pu.2 promotes erythropoiesis
Journal name Mobile DNA   Check publisher's open access policy
ISSN 1759-8753
Publication date 2014-05-09
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1759-8753-5-15
Open Access Status DOI
Volume 5
Issue 1
Total pages 4
Place of publication London, United Kingdom
Publisher BioMed Central
Collection year 2015
Language eng
Formatted abstract
Transposable elements (TEs) are a prominent feature of most eukaryotic genomes. Despite rapidly accumulating evidence for the role of TE-driven insertional mutagenesis and structural variation in genome evolution, few clear examples of individual TEs impacting biology via perturbed gene regulation are available. A recent report describes the discovery of an alternative promoter for the murine erythroid transcription factor Pu.1. This promoter is located in an ORR1A0 long terminal repeat (LTR) retrotransposon intronic to Pu.1 and is regulated by the Krüppel-like factors KLF1 and KLF3. Expression of the resultant chimeric transcript, called Pu.2, spontaneously induces erythroid differentiation in vitro. These experiments illustrate how transcription factor binding sites spread by retrotransposition have the potential to impact networks encoding key biological processes in the host genome.
Keyword Erythroid
KLF1
KLF3
LTR retrotransposon
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article # 15

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2015 Collection
School of Biomedical Sciences Publications
 
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