Expression patterns of tight junction proteins in Merkel cell carcinoma

Haass, Nikolas K., Houdek, Pia, Wladykowski, Ewa, Moll, Ingrid and Brandner, Johanna M. (2003). Expression patterns of tight junction proteins in Merkel cell carcinoma. In Klaus I. Baumann, Zdenek Halata and Ingrid Moll (Ed.), The Merkel Cell: Structure-Development-Function-Cancerogenesis. Proceedings of the International Merkel Cell Symposium, Hamburg 2002 (pp. 223-226) Berlin, Germany: Springer-Verlag. doi:10.1007/978-3-662-10358-6_32


Author Haass, Nikolas K.
Houdek, Pia
Wladykowski, Ewa
Moll, Ingrid
Brandner, Johanna M.
Title of chapter Expression patterns of tight junction proteins in Merkel cell carcinoma
Title of book The Merkel Cell: Structure-Development-Function-Cancerogenesis. Proceedings of the International Merkel Cell Symposium, Hamburg 2002
Place of Publication Berlin, Germany
Publisher Springer-Verlag
Publication Year 2003
Sub-type Research book chapter (original research)
DOI 10.1007/978-3-662-10358-6_32
Open Access Status
ISBN 9783642055744
9783662103586
Editor Klaus I. Baumann
Zdenek Halata
Ingrid Moll
Start page 223
End page 226
Total pages 4
Language eng
Formatted Abstract/Summary
Tight junctions (TJ) play a role in the barrier function of the epidermis. While Merkel cells are negative for Claudin 3, 4, 5, occludin and ZO-1, these TJ proteins are found in Merkel cell carcinoma. As TJ are able to connect neighbouring cells tightly and to control the paracellular pathway of substances, the formation of TJ might be a mechanism for a self-isolation of the tumour from its environment, especially from anti-tumorigenic cells and molecules. The synthesis of claudin 5, a marker for endothelial cells, in certain areas of Merkel cell carcinoma — in addition to blood vessels — gives a hint that a “vessel formation” might occur in this tumour.
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Book Chapter
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Created: Mon, 02 Jun 2014, 15:37:39 EST by Nikolas Haass on behalf of UQ Diamantina Institute