Adhesion, migration and communication in melanocytes and melanoma

Haass N.K., Smalley K.S.M., Li L. and Herlyn M. (2005) Adhesion, migration and communication in melanocytes and melanoma. Pigment Cell Research, 18 3: 150-159. doi:10.1111/j.1600-0749.2005.00235.x

Author Haass N.K.
Smalley K.S.M.
Li L.
Herlyn M.
Title Adhesion, migration and communication in melanocytes and melanoma
Journal name Pigment Cell Research   Check publisher's open access policy
ISSN 0893-5785
Publication date 2005
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/j.1600-0749.2005.00235.x
Volume 18
Issue 3
Start page 150
End page 159
Total pages 10
Language eng
Subject 1307 Cell Biology
1102 Cardiovascular Medicine and Haematology
1110 Nursing
1308 Clinical Biochemistry
1309 Developmental Biology
Abstract Under normal conditions, homeostasis determines whether a cell remains quiescent, proliferates, differentiates, or undergoes apoptosis. In this state of homeostasis, keratinocytes control melanocyte growth and behaviour through a complex system of paracrine growth factors and cell-cell adhesion molecules. Alteration of this delicate homeostatic balance and can lead to altered expression of cell-cell adhesion and cell communication molecules and to the development of melanoma. Melanoma cells escape from this control by keratinocytes through three major mechanisms: (1) down-regulation of receptors important for communication with keratinocytes such as E-cadherin, P-cadherin, desmoglein and connexins, which is achieved through growth factors produced by fibroblasts or keratinocytes; (2) up-regulation of receptors and signalling molecules not found on melanocytes but important for melanoma-melanoma and melanoma-fibroblast interactions such as N-cadherin, Mel-CAM, and zonula occludens protein-1 (ZO-1); (3) loss of anchorage to the basement membrane because of an altered expression of the extracellular-matrix binding integrin family. In the current review, we describe the alterations in cell-cell adhesion and communication associated with melanoma development and progression, and discuss how a greater understanding of these processes may aid the future therapy of this disease. Copyright
Keyword Cadherins
Cell adhesion molecules
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
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Citation counts: TR Web of Science Citation Count  Cited 172 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 191 times in Scopus Article | Citations
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Created: Fri, 30 May 2014, 18:25:02 EST by Nikolas Haass