Melanocytes: From morphology to application

Santiago-Walker, A., Li, L., Haass, N. K. and Herlyn M. (2009) Melanocytes: From morphology to application. Skin Pharmacology and Physiology, 22 2: 114-121. doi:10.1159/000178870


Author Santiago-Walker, A.
Li, L.
Haass, N. K.
Herlyn M.
Title Melanocytes: From morphology to application
Journal name Skin Pharmacology and Physiology   Check publisher's open access policy
ISSN 1660-5527
1660-5535
Publication date 2009
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1159/000178870
Open Access Status
Volume 22
Issue 2
Start page 114
End page 121
Total pages 8
Place of publication Basel, Switzerland
Publisher S. Karger AG
Collection year 2010
Language eng
Subject 3004 Pharmacology
1314 Physiology
2708 Dermatology
Abstract Melanocytes in human skin are intricately regulated by keratinocytes and the surrounding stroma. The development of melanoma is thought to arise from disrupted melanocyte homeostasis. It is now known that microenvironment plays a major role in maintenance of cellular homeostasis and can contribute to tumor initiation and tumor progression. Historically, melanocyte studies have been performed in two-dimensional culture systems, and often with melanocytes cultured in the absence of keratinocytes. Here we present the biological basis for the use of organotypic, three-dimensional model systems in the study of melanoma, and highlight the features of the most utilized organotypic model sytems. Copyright
Keyword Drug
Keratinocyte
Melanocyte
Melanoma
Skin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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Created: Fri, 30 May 2014, 17:59:09 EST by Nikolas Haass on behalf of UQ Diamantina Institute