Pathology of the liver sinusoids

Brunt, Elizabeth M., Gouw, Annette S. H., Hubscher, Stefan G., Tiniakos, Dina G., Bedossa, Pierre, Burt, Alastair D., Callea, Francesco, Clouston, Andrew D., Dienes, Hans P., Goodman, Zachary D., Roberts, Eve A., Roskams, Tania, Terracciano, Luigi, Torbenson, Michael S. and Wanless, Ian R. (2014) Pathology of the liver sinusoids. Histopathology, 64 7: 907-920. doi:10.1111/his.12364

Author Brunt, Elizabeth M.
Gouw, Annette S. H.
Hubscher, Stefan G.
Tiniakos, Dina G.
Bedossa, Pierre
Burt, Alastair D.
Callea, Francesco
Clouston, Andrew D.
Dienes, Hans P.
Goodman, Zachary D.
Roberts, Eve A.
Roskams, Tania
Terracciano, Luigi
Torbenson, Michael S.
Wanless, Ian R.
Title Pathology of the liver sinusoids
Journal name Histopathology   Check publisher's open access policy
ISSN 0309-0167
Publication date 2014
Year available 2014
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/his.12364
Open Access Status
Volume 64
Issue 7
Start page 907
End page 920
Total pages 14
Place of publication Chichester, West Sussex, United Kingdom
Publisher Blackwell Publishing
Collection year 2015
Language eng
Abstract The hepatic sinusoids comprise a complex of vascular conduits to transport blood from the porta hepatis to the inferior vena cava through the liver. Under normal conditions, portal venous and hepatic artery pressures are equalized within the sinusoids, oxygen and nutrients from the systemic circulation are delivered to the parenchymal cells and differentially distributed throughout the liver acini, and proteins of liver derivation are carried into the cardiac/systemic circulation. Liver sinusoid structures are lined by endothelial cells unique to their location, and Kupffer cells. Multifunctional hepatic stellate cells and various immune active cells are localized within the space of Disse between the sinusoid and the adjacent hepatocytes. Flow within the sinusoids can be compromised by physical or pressure blockage in their lumina as well as obstructive processes within the space of Disse. The intimate relationship of the liver sinusoids to neighbouring hepatocytes is a significant factor affecting the health of hepatocytes, or transmission of the effects of injury within the sinusoidal space. Pathologists should recognize several patterns of injury involving the sinusoids and surrounding hepatocytes. In this review, injury, alterations and accumulations within the liver sinusoids are illustrated and discussed.
Keyword Capillarization
Endothelial cells
Kupffer cells
Liver sinusoids
Space of Disse
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2015 Collection
School of Medicine Publications
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